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Gene Information
Gene ID:25390
Full Name:ATPase, Na+/K+ transporting, beta 3 polypeptide
Organism:Rattus norvegicus (Rat)
Genetic Location:8q31
Physical Location:101405876-101437756 on NC_005107.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 483    Symbol (Name): ATP1B3 (ATPase, Na+/K+ transporting, beta 3 polypeptide)
Ortholog Status:The human GeneID 483 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:D84450
Fold Change:2.4
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012913.1NP_037045.1NC_005107.2 range: 101405876..101437756, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0042470melanosomeCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0005391sodium:potassium-exchanging ATPase activityMolecular FunctionIDA (12562669)
GO:0005515protein bindingMolecular FunctionISS
GO:0005391sodium:potassium-exchanging ATPase activityMolecular FunctionTAS (12562669)
GO:0005391sodium:potassium-exchanging ATPase activityMolecular FunctionIEA
GO:0006814sodium ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25390