ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atp1b3

Full Name:

ATPase, Na+/K+ transporting, beta 3 polypeptide

Alias:

NKAB3S

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q31

Physical Location:

101405876-101437756 on NC_005107.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 483 Symbol (Name): ATP1B3 (ATPase, Na+/K+ transporting, beta 3 polypeptide)

Ortholog Status:

The human GeneID 483 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D84450
Fold Change:		2.4
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012913.1	NP_037045.1	NC_005107.2 range: 101405876..101437756, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042470	melanosome	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0005391	sodium:potassium-exchanging ATPase activity	Molecular Function	IDA (12562669)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005391	sodium:potassium-exchanging ATPase activity	Molecular Function	TAS (12562669)
GO:0005391	sodium:potassium-exchanging ATPase activity	Molecular Function	IEA
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	IEA