ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

St13

Full Name:

suppression of tumorigenicity 13

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q34

Physical Location:

119694122-119728935 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6767 Symbol (Name): ST13 (suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein))

Ortholog Status:

The human GeneID 6767 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X82021
Fold Change:		5.8
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031122.1	NP_112384.1	NC_005106.2 range: 119694122..119728935, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0019904	protein domain specific binding	Molecular Function	IDA (7585962)
GO:0030544	Hsp70 protein binding	Molecular Function	IDA (7585962)