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Gene Information
Gene ID:29431
Full Name:p21 (CDKN1A)-activated kinase 1
Organism:Rattus norvegicus (Rat)
Genetic Location:1q32
Physical Location:155057621-155174713 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5058    Symbol (Name): PAK1 (p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast))
Ortholog Status:The human GeneID 5058 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:NM_017198
Fold Change:6.6
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Information
Original ID1:29431
Fold Change:0.511
P Value:0.008
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017198.1NP_058894.1NC_005100.2 range: 155057621..155174713
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0005829cytosolCellular ComponentIDA (9779826)
GO:0005886plasma membraneCellular ComponentISS
GO:0030426growth coneCellular ComponentISS
GO:0030426growth coneCellular ComponentIEA
GO:0030424axonCellular ComponentISS
GO:0030424axonCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0016740transferase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0004709MAP kinase kinase kinase activityMolecular FunctionTAS (9779826)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004672protein kinase activityMolecular FunctionISS
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionTAS (8107774)
GO:0043113receptor clusteringBiological ProcessIEA
GO:0043113receptor clusteringBiological ProcessISS
GO:0043507positive regulation of JNK activityBiological ProcessISS
GO:0000165MAPKKK cascadeBiological ProcessISS
GO:0016358dendrite developmentBiological ProcessISS
GO:0016358dendrite developmentBiological ProcessIEA
GO:0007528neuromuscular junction developmentBiological ProcessISS
GO:0007528neuromuscular junction developmentBiological ProcessIEA
GO:0007264small GTPase mediated signal transductionBiological ProcessTAS (8107774)
GO:0007243protein kinase cascadeBiological ProcessTAS (9779826)
GO:0006468protein amino acid phosphorylationBiological ProcessTAS (9779826)
GO:0046777protein amino acid autophosphorylationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29431