Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:5058
Full Name:p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
Organism:Homo sapiens (Human)
Genetic Location:11q13-q14
Physical Location:76710707-76862580 on NC_000011.8, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 29431 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U24152
Fold Change:-3.07
Dataset Information
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Information
Original ID1:PAK1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002576.4NP_002567.3NC_000011.8 range: 76710707..76862580, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (16278681)
GO:0030054cell junctionCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIDA (16278681)
GO:0016740transferase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12624090|12879077|15350535|16278681)
GO:0004674protein serine/threonine kinase activityMolecular FunctionTAS (16278681)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0043507positive regulation of JNK activityBiological ProcessIMP (8805275)
GO:0000165MAPKKK cascadeBiological ProcessIDA (8805275)
GO:0007010cytoskeleton organization and biogenesisBiological ProcessTAS (16278681)
GO:0006984ER-nuclear signaling pathwayBiological ProcessTAS (16278681)
GO:0006915apoptosisBiological ProcessIEA
GO:0046777protein amino acid autophosphorylationBiological ProcessIDA (8805275)
Other Database Cross Links
NCBI Entrez Gene:5058
HuGE Navigator:5058