ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PAK1

Full Name:

p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

Alias:

MGC130000|MGC130001|PAKalpha

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11q13-q14

Physical Location:

76710707-76862580 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 29431 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U24152
Fold Change:		-3.07

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

PAK1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002576.4	NP_002567.3	NC_000011.8 range: 76710707..76862580, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (16278681)
GO:0030054	cell junction	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (16278681)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12624090\|12879077\|15350535\|16278681)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (16278681)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0043507	positive regulation of JNK activity	Biological Process	IMP (8805275)
GO:0000165	MAPKKK cascade	Biological Process	IDA (8805275)
GO:0007010	cytoskeleton organization and biogenesis	Biological Process	TAS (16278681)
GO:0006984	ER-nuclear signaling pathway	Biological Process	TAS (16278681)
GO:0006915	apoptosis	Biological Process	IEA
GO:0046777	protein amino acid autophosphorylation	Biological Process	IDA (8805275)