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Dataset Description
  • Dataset Name: 15236863
  • Species: Human
  • Method: Microarray
  • No. of Genes: 77
  • Tissue: Prefrontal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
  • Dataset Summary: We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

    Gene list of this dataset (77 genes)
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    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    3726JUNBjun B proto-oncogene19p13.2X51345 
    26047CNTNAP2contactin associated protein-like 27q35-q36AB020675 
    5058PAK1p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)11q13-q14U24152 
    523ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A3q13.2-q13.31L09235 
    972CD74CD74 molecule, major histocompatibility complex, class II invariant chain5q32M13560 
    5911RAP2ARAP2A, member of RAS oncogene family13q34X12534 
    4131MAP1Bmicrotubule-associated protein 1B5q13L06237 
    10922FASTKFas-activated serine/threonine kinase7q35X86779 
    3122HLA-DRAmajor histocompatibility complex, class II, DR alpha6p21.3J00194 
    3164NR4A1nuclear receptor subfamily 4, group A, member 112q13L13740 
    1375CPT1Bcarnitine palmitoyltransferase 1B (muscle)22q13.33AL096780 
    4744NEFHneurofilament, heavy polypeptide 200kDa22q12.2X15306 
    23157SEPT6septin 6Xq24W25951 
    1006CDH8cadherin 8, type 216q22.1L34060 
    10370CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 26q23.3U65093 
    5121PCP4Purkinje cell protein 421q22.2U52969 
    7644ZNF91zinc finger protein 9119p13.1-p12L11672 
    6505SLC1A1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 19p24AI928365 
    6935ZEB1zinc finger E-box binding homeobox 110p11.2D15050 
    3115HLA-DPB1major histocompatibility complex, class II, DP beta 16p21.3M83664 
    5714PSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 819q13.2D38047 
    5296PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)19q13.2-q13.4X80907 
    10681GNB5guanine nucleotide binding protein (G protein), beta 515q21.2AF017656 
    3304HSPA1Bheat shock 70kDa protein 1B6p21.3M59830 
    4336MOBPmyelin-associated oligodendrocyte basic protein3p22.1D28113 
    79073TMEM109transmembrane protein 10911q12.2N53547 
    1573CYP2J2cytochrome P450, family 2, subfamily J, polypeptide 21p31.3-p31.2U37143 
    684BST2bone marrow stromal cell antigen 219p13.2D28137 
    23194FBXL7F-box and leucine-rich repeat protein 75p15.1AB020647 
    5653KLK6kallikrein-related peptidase 619q13.3U62801 
    8940TOP3Btopoisomerase (DNA) III beta22q11.22D87012 
    6576SLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 122q11.21L77567 
    4355MPP2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)17q12-q21X82895 
    83700JAM3junctional adhesion molecule 311q25AA149644 
    9448MAP4K4mitogen-activated protein kinase kinase kinase kinase 42q11.2-q12AB014587 
    400961PAIP2Bpoly(A) binding protein interacting protein 2B2p13.3AA648931 
    4118MALmal, T-cell differentiation protein2cen-q13X76220 
    1410CRYABcrystallin, alpha B11q22.3-q23.1AL038340 
    3315HSPB1heat shock 27kDa protein 17q11.23Z23090 
    183AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)1q42-q43K02215 
    2052EPHX1epoxide hydrolase 1, microsomal (xenobiotic)1q42.1L25879 
    10581IFITM2interferon induced transmembrane protein 2 (1-8D)11p15.5X57351 
    8502PKP4plakophilin 42q23-q31X81889 
    64386MMP25matrix metallopeptidase 2516p13.3AJ003147 
    7368UGT8UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)4q26U30930 
    23209MLC1megalencephalic leukoencephalopathy with subcortical cysts 122q13.33D25217 
    4915NTRK2neurotrophic tyrosine kinase, receptor, type 29q22.1AI018523 
    5156PDGFRAplatelet-derived growth factor receptor, alpha polypeptide4q11-q13M21574 
    10979FERMT2fermitin family homolog 2 (Drosophila)14q22.2Z24725 
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