ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NEFH

Full Name:

neurofilament, heavy polypeptide 200kDa

Alias:

NFH

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q12.2

Physical Location:

28206218-28217278 on NC_000022.9

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 24587 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AB020652

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:		X15306
Fold Change:		-2.36

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

NEFH

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021076.2	NP_066554.2	NC_000022.9 range: 28206218..28217278

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000786	nucleosome	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005883	neurofilament	Cellular Component	NAS (3138108)
GO:0030424	axon	Cellular Component	TAS (14662745)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0006334	nucleosome assembly	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	NAS