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Gene Information
Gene ID:4744
Symbol:NEFH
Full Name:neurofilament, heavy polypeptide 200kDa
Alias:NFH
Organism:Homo sapiens (Human)
Chromosome:22
Genetic Location:22q12.2
Physical Location:28206218-28217278 on NC_000022.9
Gene Type:protein-coding
Orthologs:This gene has Rat: 24587 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB020652
Dataset Information
Name:12065639
Method:Microarray
Tissue:Frontal and motor cortices
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.
Gene Information
Original ID1:X15306
Fold Change:-2.36
Dataset Information
Name:15236863
Method:Microarray
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Information
Original ID1:NEFH
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_021076.2NP_066554.2NC_000022.9 range: 28206218..28217278
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000786nucleosomeCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005883neurofilamentCellular ComponentNAS (3138108)
GO:0030424axonCellular ComponentTAS (14662745)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0006334nucleosome assemblyBiological ProcessIEA
GO:0007399nervous system developmentBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:4744
HGNC:7737
Ensembl:ENSG00000100285
MIM:162230
HPRD:01204
HuGE Navigator:4744
dbSNP:NEFH
GeneCard:NEFH
AceView:NEFH