ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nefh

Full Name:

neurofilament, heavy polypeptide

Alias:

Nfh

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14q21

Physical Location:

85595270-85604773 on NC_005113.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4744 Symbol (Name): NEFH (neurofilament, heavy polypeptide 200kDa)

Ortholog Status:

The human GeneID 4744 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012607.2	NP_036739.2	NC_005113.2 range: 85595270..85604773, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005882	intermediate filament	Cellular Component	IEA
GO:0005883	neurofilament	Cellular Component	ISS
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (2230956)
GO:0000226	microtubule cytoskeleton organization and biogenesis	Biological Process	ISS
GO:0045104	intermediate filament cytoskeleton organization and biogenesis	Biological Process	ISS
GO:0045110	intermediate filament bundle assembly	Biological Process	ISS
GO:0060052	neurofilament cytoskeleton organization and biogenesis	Biological Process	ISS