ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSMD8

Full Name:

proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

Alias:

HIP6|HYPF|MGC1660|Nin1p|Rpn12|S14|p31

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19q13.2

Physical Location:

43557029-43566303 on NC_000019.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D38047
Fold Change:		-2.03

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002812.4	NP_002803.2	NC_000019.8 range: 43557029..43566303

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000502	proteasome complex	Cellular Component	TAS (8811196)
GO:0005829	cytosol	Cellular Component	IEA
GO:0005838	proteasome regulatory particle	Cellular Component	IEA
GO:0005838	proteasome regulatory particle	Cellular Component	TAS (7621825)
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0006508	proteolysis	Biological Process	IEA
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (15029244)
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)