| Gene Information |
| Gene ID: | | 183 |
| Symbol: | | AGT |
| Full Name: | | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| Alias: | | ANHU|FLJ92595|FLJ97926|SERPINA8 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 1 |
| Genetic Location: | | 1q42-q43 |
| Physical Location: | | 228904891-228916563 on NC_000001.9, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has Rat: 24179 ortholog(s) in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | K02215 | | Fold Change: | | -1.7, -1.6 | | Note: | | Differential expression on the oligonucleotide array (two fold changes are from two case groups) |
| | Dataset Information | | Name: | | 11141048 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed | | Summary: | | RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. |
| | Gene Information | | Original ID1: | | K02215 | | Fold Change: | | 2.6 |
| | Dataset Information | | Name: | | 15236863 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed | | Summary: | | We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes. |
| | Gene Information | | Original ID1: | | Hs.19383 | | Note: | | "Class I, down-regulated gene" |
| | Dataset Information | | Name: | | 16292326 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed | | Summary: | | In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05. |
| | Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Gene Information | | Original ID | No. of Publications | Phenotype | |
| AGT | 1 | Alcohol-Induced Disorders | | AGT | 1 | Alcoholism | | AGT | 2 | Alcohol-Related Disorders |
| | HuGE Navigator Dataset | | Name: | | HuGE Navigator | | Method: | | Literature data mining | | Publication: | | Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008]. | | Summary: | | HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | NAS (14718574) | |
| GO:0005625 | soluble fraction | Cellular Component | TAS (6089875) | |
| GO:0004867 | serine-type endopeptidase inhibitor activity | Molecular Function | TAS (3397061) | |
| GO:0005179 | hormone activity | Molecular Function | NR | |
| GO:0007166 | cell surface receptor linked signal transduction | Biological Process | TAS (8477848) | |
| GO:0007267 | cell-cell signaling | Biological Process | TAS (8513325) | |
| GO:0007565 | female pregnancy | Biological Process | TAS (8513325) | |
| GO:0008217 | regulation of blood pressure | Biological Process | TAS (8513325) | |
| GO:0042310 | vasoconstriction | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 183 |
| HGNC: | | 333 |
| Ensembl: | | ENSG00000135744 |
| MIM: | | 106150 |
| HPRD: | | 00106 |
| HuGE Navigator: | | 183 |
| dbSNP: | | AGT |
| GeneCard: | | AGT |
| AceView: | | AGT |
