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Gene Information
Gene ID:24179
Symbol:Agt
Full Name:angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Alias:ANRT|Ang|AngII|MGC105326|PAT
Organism:Rattus norvegicus (Rat)
Chromosome:19
Genetic Location:19q12
Physical Location:54738555-54750348 on NC_005118.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 183    Symbol (Name): AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))
Ortholog Status:The human GeneID 183 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Agt
Fold Change:1.3
Tissue:Caudate-putamen
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134432.2NP_602308.1NC_005118.2 range: 54738555..54750348, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentISS
GO:0044444cytoplasmic partCellular ComponentIDA (12242043)
GO:0031703type 2 angiotensin receptor bindingMolecular FunctionIMP (16286564)
GO:0031703type 2 angiotensin receptor bindingMolecular FunctionISS
GO:0031703type 2 angiotensin receptor bindingMolecular FunctionIEA
GO:0031702type 1 angiotensin receptor bindingMolecular FunctionISS
GO:0031702type 1 angiotensin receptor bindingMolecular FunctionIMP (16286564)
GO:0031702type 1 angiotensin receptor bindingMolecular FunctionIEA
GO:0031701angiotensin receptor bindingMolecular FunctionIMP (11282364|15951342)
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionIEA
GO:0004937alpha1-adrenergic receptor activityMolecular FunctionTAS (9931144)
GO:0030198extracellular matrix organization and biogenesisBiological ProcessIEA
GO:0042445hormone metabolic processBiological ProcessIEA
GO:0030147natriuresisBiological ProcessIMP (16380540)
GO:0040018positive regulation of multicellular organism growthBiological ProcessISS
GO:0040018positive regulation of multicellular organism growthBiological ProcessIEA
GO:0030308negative regulation of cell growthBiological ProcessIMP (15951342)
GO:0030198extracellular matrix organization and biogenesisBiological ProcessISS
GO:0030432peristalsisBiological ProcessISS
GO:0030432peristalsisBiological ProcessIEA
GO:0030147natriuresisBiological ProcessIDA (11390024)
GO:0043085positive regulation of catalytic activityBiological ProcessIMP (11100981)
GO:0051145smooth muscle cell differentiationBiological ProcessIEA
GO:0048659smooth muscle cell proliferationBiological ProcessISS
GO:0048659smooth muscle cell proliferationBiological ProcessIEA
GO:0048169regulation of long-term neuronal synaptic plasticityBiological ProcessIMP (11282364)
GO:0048143astrocyte activationBiological ProcessISS
GO:0048143astrocyte activationBiological ProcessIEA
GO:0046622positive regulation of organ growthBiological ProcessISS
GO:0046622positive regulation of organ growthBiological ProcessIEA
GO:0045723positive regulation of fatty acid biosynthetic processBiological ProcessISS
GO:0045723positive regulation of fatty acid biosynthetic processBiological ProcessIEA
GO:0043524negative regulation of neuron apoptosisBiological ProcessISS
GO:0043524negative regulation of neuron apoptosisBiological ProcessIEA
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessISS
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessIEA
GO:0042756drinking behaviorBiological ProcessISS
GO:0042756drinking behaviorBiological ProcessIEA
GO:0042445hormone metabolic processBiological ProcessISS
GO:0051145smooth muscle cell differentiationBiological ProcessISS
GO:0014061regulation of norepinephrine secretionBiological ProcessIMP (11100981)
GO:0002019regulation of renal output by angiotensinBiological ProcessIEA
GO:0002018renin-angiotensin regulation of aldosterone productionBiological ProcessISS
GO:0002018renin-angiotensin regulation of aldosterone productionBiological ProcessIEA
GO:0001999renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressureBiological ProcessISS
GO:0001999renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressureBiological ProcessIEA
GO:0001998angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressureBiological ProcessISS
GO:0001998angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressureBiological ProcessIEA
GO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinBiological ProcessISS
GO:0001822kidney developmentBiological ProcessISS
GO:0001822kidney developmentBiological ProcessIEA
GO:0001658ureteric bud branchingBiological ProcessISS
GO:0001658ureteric bud branchingBiological ProcessISS
GO:0001658ureteric bud branchingBiological ProcessIEA
GO:0001568blood vessel developmentBiological ProcessISS
GO:0001568blood vessel developmentBiological ProcessIEA
GO:0001543ovarian follicle ruptureBiological ProcessISS
GO:0002019regulation of renal output by angiotensinBiological ProcessISS
GO:0002035brain renin-angiotensin systemBiological ProcessIEA
GO:0002035brain renin-angiotensin systemBiological ProcessISS
GO:0009651response to salt stressBiological ProcessISS
GO:0009409response to coldBiological ProcessISS
GO:0009409response to coldBiological ProcessIEA
GO:0008285negative regulation of cell proliferationBiological ProcessISS
GO:0008285negative regulation of cell proliferationBiological ProcessIEA
GO:0008217regulation of blood pressureBiological ProcessISS
GO:0008217regulation of blood pressureBiological ProcessIEP (12468106)
GO:0008065establishment of blood-nerve barrierBiological ProcessISS
GO:0008065establishment of blood-nerve barrierBiological ProcessIEA
GO:0007588excretionBiological ProcessISS
GO:0007202activation of phospholipase C activityBiological ProcessIMP (11100981)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIMP (16286564)
GO:0007166cell surface receptor linked signal transductionBiological ProcessIDA (12130563)
GO:0007160cell-matrix adhesionBiological ProcessISS
GO:0007160cell-matrix adhesionBiological ProcessIEA
GO:0006883cellular sodium ion homeostasisBiological ProcessIMP (16380540)
GO:0001543ovarian follicle ruptureBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:24179
RGD:2069
Ensembl:ENSRNOG00000018445
dbSNP:Agt