ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MAP1B

Full Name:

microtubule-associated protein 1B

Alias:

DKFZp686E1099|DKFZp686F1345|FLJ38954|FUTSCH|MAP5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q13

Physical Location:

71438873-71541152 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 29456 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L06237
Fold Change:		-2.49

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

MAP1B

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S647

66282906

Region:		66282906-76193808
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005909.3	NP_005900.2	NC_000005.8 range: 71438873..71541152

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005875	microtubule associated complex	Cellular Component	TAS (1881920)
GO:0005198	structural molecule activity	Molecular Function	NAS (1881920)
GO:0005515	protein binding	Molecular Function	IPI (12147674)