ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Map1b

Full Name:

microtubule-associated protein 1b

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q12

Physical Location:

30415234-30508353 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4131 Symbol (Name): MAP1B (microtubule-associated protein 1B)

Ortholog Status:

The human GeneID 4131 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Map1b
Fold Change:		-1.34
P Value:		0
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Map1b
Fold Change:		-1.37
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_215469.4	XP_215469.2	NC_005101.2 range: 30415234..30508353, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043025	cell soma	Cellular Component	IDA (7908909)
GO:0030425	dendrite	Cellular Component	IDA (7908909)
GO:0030424	axon	Cellular Component	IDA (7908909)
GO:0005875	microtubule associated complex	Cellular Component	IDA (7908909\|11896150)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (7908909)
GO:0005515	protein binding	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	IDA (11896150)
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IDA (11896150)
GO:0016358	dendrite development	Biological Process	IEA
GO:0016358	dendrite development	Biological Process	ISS
GO:0001578	microtubule bundle formation	Biological Process	ISS
GO:0001578	microtubule bundle formation	Biological Process	IEA