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Gene Information
Gene ID:10370
Full Name:Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Organism:Homo sapiens (Human)
Genetic Location:6q23.3
Physical Location:139735088-139737477 on NC_000006.10, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 17684 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U65093
Fold Change:-2.13
Dataset Information
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Information
Original ID1:CITED2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D6S308  141298258
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006079.3NP_006070.2NC_000006.10 range: 139735088..139737477, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentNAS (10552932)
GO:0003700transcription factor activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionNAS (10552932)
GO:0045787positive regulation of cell cycleBiological ProcessISS
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayBiological ProcessISS
GO:0007507heart developmentBiological ProcessISS
GO:0007507heart developmentBiological ProcessIMP (16287139)
GO:0007368determination of left/right symmetryBiological ProcessISS
GO:0006950response to stressBiological ProcessIEA
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (9434189)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:10370
HuGE Navigator:10370