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Gene Information
Gene ID:17684
Full Name:Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Organism:Mus musculus (Mouse)
Genetic Location:10 A2
Physical Location:17443051-17445461 on NC_000076.5
Gene Type:protein-coding
Human Ortholog:GeneID: 10370    Symbol (Name): CITED2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2)
Ortholog Status:The human GeneID 10370 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1417129 (probe)
Original ID2:Mrg1
Fold Change:1.2
P Value:2.20E-04
Note:Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:4.3
Dataset Information
Method:Microarray and QTL
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010828.2NP_034958.2NC_000076.5 range: 17443051..17445461
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (9811838)
GO:0005515protein bindingMolecular FunctionIPI (16619037)
GO:0030528transcription regulator activityMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIDA (9811838)
GO:0003712transcription cofactor activityMolecular FunctionTAS (11823447)
GO:0007507heart developmentBiological ProcessISS (9887100)
GO:0030325adrenal gland developmentBiological ProcessIMP (15615595)
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayBiological ProcessIDA (16619037)
GO:0001568blood vessel developmentBiological ProcessIMP (15615595)
GO:0045449regulation of transcriptionBiological ProcessIEA
GO:0045787positive regulation of cell cycleBiological ProcessIMP (9811838)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessIDA (9811838)
GO:0046697decidualizationBiological ProcessIMP (16579983)
GO:0007507heart developmentBiological ProcessIMP (15750185)
GO:0007417central nervous system developmentBiological ProcessIMP (11823447)
GO:0007368determination of left/right symmetryBiological ProcessIMP (15750185)
GO:0001570vasculogenesisBiological ProcessIMP (16579983)
GO:0001701in utero embryonic developmentBiological ProcessIMP (16579983)
GO:0001829trophectodermal cell differentiationBiological ProcessIMP (16579983)
GO:0001892embryonic placenta developmentBiological ProcessIMP (16579983)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessTAS (11823447)
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (15475956)
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessRCA (12466851)
GO:0060136embryonic process involved in female pregnancyBiological ProcessIMP (16579983)
Other Database Cross Links
NCBI Entrez Gene:17684