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Dataset Description
  • Dataset Name: 15597075
  • Species: Mouse
  • Method: Microarray and QTL
  • No. of Genes: 58
  • Tissue: Brain
  • Phenotype: Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
  • Publication: Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
  • Dataset Summary: Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

    Gene list of this dataset (58 genes)
    Page: 1 2 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    15939Ier5immediate early response 51 G3|1 81.5 cM1460009 (probe)Ier5
    14455Gas5growth arrest specific 51 H2.11449410 (probe)Gas5
    17926Myocmyocilin1 H2.1|1 83.6 cM1450468 (probe)Myoc
    16579Kifap3kinesin-associated protein 31 H11451783 (probe)Kifap3
        1419716 (probe)Pou2fl
    66447Mgst3microsomal glutathione S-transferase 31 H21448300 (probe)Mgst3
    56009Refbp2RNA and export factor binding protein 21 H31422993 (probe)Refbp2
    12847Copacoatomer protein complex subunit alpha1 H3|1 93.5 cM1415706 (probe)Copa
        1434893 (probe)EST
        1455136 (probe)EST
    16524Kcnj9potassium inwardly-rectifying channel, subfamily J, member 91 H3|1 94.2 cM1426115 (probe)Kcnj9
        1419601 (probe)Kenj10
    13349DarcDuffy blood group, chemokine receptor1 H3|1 94.0 cM1432273 (probe)Dfy
    226695Ifi205interferon activated gene 2051 H3|1 95.3 cM1426906 (probe)Ifi205
    54418Fmn2formin 21 H3|1 96.0 cM1431725 (probe)Fmn2
        1423871 (probe)EST
        1453018 (probe)cDNA
        1429763 (probe)cDNA
    12509Cd59aCD59a antigen2 55.0 cM1429830 (probe)Cd59a
    20394Scg5secretogranin V2 E5|2 64.0 cM1423150 (probe)Sgne1
        1425343 (probe)cDNA
    17025Aladaminolevulinate, delta-, dehydratase4 B3|4 30.6 cM1424877 (probe)Alad
    17475Mpdzmultiple PDZ domain protein4 C3|4 38.6 cM1418664 (probe)Mpdz
        1428760 (probe)cDNA
    20104Rps6ribosomal protein S64 C31416142 (probe)Rps6
    230379Asah3lN-acylsphingosine amidohydrolase 3-like4 C41451355 (probe)CRG-L1
        1450967 (probe)cDNA
        1448250 (probe)cDNA
    20660Sorl1sortilin-related receptor, LDLR class A repeats-containing-1426258 (probe)Sorl1
    235293Sc5dsterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)9 B1451457 (probe)Sc5d
    17967Ncam1neural cell adhesion molecule 19 A5.3|9 28.0 cM1426865 (probe)Ncam1
    12955Cryabcrystallin, alpha B9 A5.3|9 29.0 cM1416455 (probe)Cryab
        1417211 (probe)cDNA
        1448845 (probe)EST
    22003Tpm1tropomyosin 1, alpha9 C|9 40.0 cM1423049 (probe)Tpm1
    59046Arpp19cAMP-regulated phosphoprotein 199 E11450685 (probe)Arpp19
    70769Nolc1nucleolar and coiled-body phosphoprotein 119 C31428870 (probe)Nolc1
    13669Eif3s10eukaryotic translation initiation factor 3, subunit 10 (theta)19 D1448425 (probe)Eif3s10
    94281Sfxn4sideroflexin 419 D31418873 (probe)Sfxn4
        1455072 (probe)cDNA
    26374Rfwd2ring finger and WD repeat domain 21 C31426912 (probe)Cop1
    64659Mrps14mitochondrial ribosomal protein S141 H2.11420489 (probe)Mrps14
    56752Aldh9a1aldehyde dehydrogenase 9, subfamily A11 H21437388 (probe)Aldh9a1
        1448630 (probe)Sdhe
        1429382 (probe)EST
    226646Ndufs2NADH dehydrogenase (ubiquinone) Fe-S protein 21 H31451096 (probe)Ndufs2
        1421096 (probe)Pdfn2
    98193Wdr42aWD repeat domain 42A1 H31434133 (probe)D1Ucla4
    98660Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide1 H3|1 94.2 cM1427465 (probe)Atp1a2
    94332Cadm3cell adhesion molecule 31 H31418921 (probe)Necl1
    Page: 1 2 list all