| Gene Information |
| Gene ID: | | 13349 |
| Symbol: | | Darc |
| Full Name: | | Duffy blood group, chemokine receptor |
| Alias: | | AA162249|CCBP1|CD234|Dfy|ESTM35|FY|GPD |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 H3|1 94.0 cM |
| Physical Location: | | 175262016-175263633 on NC_000067.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 2532 Symbol (Name): DARC (Duffy blood group, chemokine receptor) |
| Ortholog Status: | | The human GeneID 2532 is also in human dataset(s). |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 1432273 (probe) | | Original ID2: | | Dfy | | Fold Change: | | 1.37 | | P Value: | | 1.30E-06 | | Note: | | Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:14 |
| | Gene Information | | Original ID1: | | 93412 (probe) | | Original ID2: | | Dfy | | Fold Change: | | 1.4 | | P Value: | | 2.00E-05 | | Note: | | Highest priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:3.0 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
|
|
| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Alcw1 | Acute Alcohol Withdrawal | 1 | 96 | 172.3-176.5 (Mb) | 5.6 | 3.00E-07 | Significant | PARC | | Calw1/Alcdp1 | Chronic Alcohol Withdrawal | 1 | 96 | 89-106.3 (cM) | 7.6 | 2.00E-09 | Significant | PARC | | Ap1q | Alcohol Preference Drinking | 1 | 76 | 45-95 (cM) | 4.5 | | Significant | PARC |
|
|
| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | RCA (12466851) | |
| GO:0001584 | rhodopsin-like receptor activity | Molecular Function | IEA | |
| GO:0004871 | signal transducer activity | Molecular Function | IEA | |
| GO:0004872 | receptor activity | Molecular Function | IEA | |
| GO:0004930 | G-protein coupled receptor activity | Molecular Function | IEA | |
| GO:0006954 | inflammatory response | Biological Process | IMP (10961863) | |
| GO:0007165 | signal transduction | Biological Process | IEA | |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | Biological Process | IEA | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 13349 |
| MGI: | |
| Ensembl: | | ENSMUSG00000037872 |
| dbSNP: | | Darc |
| AceView: | | Darc |
