ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cadm3

Full Name:

cell adhesion molecule 3

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H3

Physical Location:

175264384-175297825 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 57863 Symbol (Name): CADM3 (cell adhesion molecule 3)

Ortholog Status:

The human GeneID 57863 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1418921 (probe)
Original ID2:		Necl1
Fold Change:		1.11
P Value:		4.40E-04
Note:		Moderate priority differential expression on 430A array. Direction: D2>B6; Cis LOD:1.2

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053199.3	NP_444429.1	NC_000067.5 range: 175264384..175297825, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030054	cell junction	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005911	intercellular junction	Cellular Component	IDA (15893517)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	IDA (12826663)
GO:0005515	protein binding	Molecular Function	IEA
GO:0008104	protein localization	Biological Process	IMP (15893517)
GO:0007156	homophilic cell adhesion	Biological Process	IDA (12826663)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0007157	heterophilic cell adhesion	Biological Process	IDA (12826663)