| Gene Information |
| Gene ID: | | 17926 |
| Symbol: | | Myoc |
| Full Name: | | myocilin |
| Alias: | | AI957332|GLC1A|MGC159032|TIGR |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 H2.1|1 83.6 cM |
| Physical Location: | | 164569299-164579823 on NC_000067.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 4653 Symbol (Name): MYOC (myocilin, trabecular meshwork inducible glucocorticoid response) |
| Ortholog Status: | | The human GeneID 4653 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 1450468 (probe) | | Original ID2: | | Myoc | | Fold Change: | | 2.35 | | P Value: | | 1.80E-02 | | Note: | | Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:6.3 |
| | Gene Information | | Original ID1: | | 94122 (probe) | | Original ID2: | | Myoc | | Fold Change: | | 4.6 | | P Value: | | 2.70E-09 | | Note: | | Highest priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:2.2 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
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| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Ap1q | Alcohol Preference Drinking | 1 | 76 | 45-95 (cM) | 4.5 | | Significant | PARC |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0042995 | cell projection | Cellular Component | IEA | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0005929 | cilium | Cellular Component | IEA | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IEA | |
| GO:0005615 | extracellular space | Cellular Component | RCA (12466851) | |
| GO:0005615 | extracellular space | Cellular Component | ISS (17317787) | |
| GO:0005615 | extracellular space | Cellular Component | IDA (12019210) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0016524 | latrotoxin receptor activity | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | IPI (12019210) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 17926 |
| MGI: | |
| Ensembl: | | ENSMUSG00000026697 |
| dbSNP: | | Myoc |
| AceView: | | Myoc |
