| Gene Information |
| Gene ID: | | 26374 |
| Symbol: | | Rfwd2 |
| Full Name: | | ring finger and WD repeat domain 2 |
| Alias: | | AI316802|C80879|Cop1 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 C3 |
| Physical Location: | | 161162456-161277710 on NC_000067.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 64326 Symbol (Name): RFWD2 (ring finger and WD repeat domain 2) |
| Ortholog Status: | | The human GeneID 64326 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 1426912 (probe) | | Original ID2: | | Cop1 | | Fold Change: | | 1.1 | | P Value: | | 5.50E-05 | | Note: | | Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:1.7 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005575 | cellular_component | Cellular Component | ND | |
| GO:0005634 | nucleus | Cellular Component | IEA | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0003674 | molecular_function | Molecular Function | ND | |
| GO:0016874 | ligase activity | Molecular Function | IEA | |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | |
| GO:0046872 | metal ion binding | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | IEA | |
| GO:0008150 | biological_process | Biological Process | ND | |
| GO:0006512 | ubiquitin cycle | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 26374 |
| MGI: | |
| Ensembl: | | ENSMUSG00000040782 |
| dbSNP: | | Rfwd2 |
| AceView: | | Rfwd2 |
