ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ndufs2

Full Name:

NADH dehydrogenase (ubiquinone) Fe-S protein 2

Alias:

AL033311|MGC27667

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H3

Physical Location:

173164990-173177242 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4720 Symbol (Name): NDUFS2 (NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase))

Ortholog Status:

The human GeneID 4720 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1451096 (probe)
Original ID2:		Ndufs2
Fold Change:		1.19
P Value:		2.10E-04
Note:		Moderate priority differential expression on 430A array. Direction: D2>B6; Cis LOD:3.3

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_153064.4	NP_694704.1	NC_000067.5 range: 173164990..173177242, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005746	mitochondrial respiratory chain	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0051536	iron-sulfur cluster binding	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016651	oxidoreductase activity, acting on NADH or NADPH	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0009053	electron donor activity	Molecular Function	IEA
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Molecular Function	IEA
GO:0051539	4 iron, 4 sulfur cluster binding	Molecular Function	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0006810	transport	Biological Process	IEA