ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

98660

Symbol:

Atp1a2

Full Name:

ATPase, Na+/K+ transporting, alpha 2 polypeptide

Alias:

AW060654|Atpa-3|mKIAA0778

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H3|1 94.2 cM

Physical Location:

174201839-174228194 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 477 Symbol (Name): ATP1A2 (ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide)

Ortholog Status:

The human GeneID 477 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Atp1a2

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Information

Original ID1:		1427465 (probe)
Original ID2:		Atp1a2
Fold Change:		2.13
P Value:		4.70E-11
Note:		Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:13.4

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_178405.3	NP_848492.1	NC_000067.5 range: 174201839..174228194, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042383	sarcolemma	Cellular Component	IDA (15485817)
GO:0005792	microsome	Cellular Component	IDA (11557593)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15485817)
GO:0005391	sodium:potassium-exchanging ATPase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0015672	monovalent inorganic cation transport	Biological Process	IEA
GO:0045988	negative regulation of striated muscle contraction	Biological Process	IMP (11507009)
GO:0045822	negative regulation of heart contraction	Biological Process	IMP (10360172)
GO:0019229	regulation of vasoconstriction	Biological Process	IGI (14627611)
GO:0019229	regulation of vasoconstriction	Biological Process	IMP (14627611)
GO:0040011	locomotion	Biological Process	IMP (12458206)
GO:0008542	visual learning	Biological Process	IMP (17234593)
GO:0001504	neurotransmitter uptake	Biological Process	IMP (12805306)
GO:0002026	regulation of the force of heart contraction	Biological Process	IMP (10360172)
GO:0002087	neurological control of breathing	Biological Process	IMP (12458206\|15564586)
GO:0006810	transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006812	cation transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0006937	regulation of muscle contraction	Biological Process	IMP (10360172)
GO:0006940	regulation of smooth muscle contraction	Biological Process	IMP (14627611)
GO:0006942	regulation of striated muscle contraction	Biological Process	IMP (15253893)
GO:0008152	metabolic process	Biological Process	IEA
GO:0008217	regulation of blood pressure	Biological Process	IGI (16243970)
GO:0008344	adult locomotory behavior	Biological Process	IMP (17234593)
GO:0051481	reduction of cytosolic calcium ion concentration	Biological Process	IMP (10360172)