ERGR - Ethanol-Related Gene Resource

Dataset Description

Dataset Name: 15597075

Species: Mouse

No. of Genes: 58

Tissue: Brain

Phenotype: Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity

Publication: Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed

Dataset Summary: Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene list of this dataset (58 genes)

GeneID Symbol Name Genetic location Original ID1 Original ID2
15939 Ier5 immediate early response 5 1 G3|1 81.5 cM 1460009 (probe) Ier5
14455 Gas5 growth arrest specific 5 1 H2.1 1449410 (probe) Gas5
17926 Myoc myocilin 1 H2.1|1 83.6 cM 1450468 (probe) Myoc
16579 Kifap3 kinesin-associated protein 3 1 H1 1451783 (probe) Kifap3
1419716 (probe) Pou2fl
66447 Mgst3 microsomal glutathione S-transferase 3 1 H2 1448300 (probe) Mgst3
56009 Refbp2 RNA and export factor binding protein 2 1 H3 1422993 (probe) Refbp2
12847 Copa coatomer protein complex subunit alpha 1 H3|1 93.5 cM 1415706 (probe) Copa
1434893 (probe) EST
1455136 (probe) EST
16524 Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 1 H3|1 94.2 cM 1426115 (probe) Kcnj9
1419601 (probe) Kenj10
13349 Darc Duffy blood group, chemokine receptor 1 H3|1 94.0 cM 1432273 (probe) Dfy
226695 Ifi205 interferon activated gene 205 1 H3|1 95.3 cM 1426906 (probe) Ifi205
54418 Fmn2 formin 2 1 H3|1 96.0 cM 1431725 (probe) Fmn2
1423871 (probe) EST
1453018 (probe) cDNA
1429763 (probe) cDNA
12509 Cd59a CD59a antigen 2 55.0 cM 1429830 (probe) Cd59a
20394 Scg5 secretogranin V 2 E5|2 64.0 cM 1423150 (probe) Sgne1
1425343 (probe) cDNA
17025 Alad aminolevulinate, delta-, dehydratase 4 B3|4 30.6 cM 1424877 (probe) Alad
17475 Mpdz multiple PDZ domain protein 4 C3|4 38.6 cM 1418664 (probe) Mpdz
1428760 (probe) cDNA
20104 Rps6 ribosomal protein S6 4 C3 1416142 (probe) Rps6
230379 Asah3l N-acylsphingosine amidohydrolase 3-like 4 C4 1451355 (probe) CRG-L1
1450967 (probe) cDNA
1448250 (probe) cDNA
20660 Sorl1 sortilin-related receptor, LDLR class A repeats-containing - 1426258 (probe) Sorl1
235293 Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) 9 B 1451457 (probe) Sc5d
17967 Ncam1 neural cell adhesion molecule 1 9 A5.3|9 28.0 cM 1426865 (probe) Ncam1
12955 Cryab crystallin, alpha B 9 A5.3|9 29.0 cM 1416455 (probe) Cryab
1417211 (probe) cDNA
1448845 (probe) EST
22003 Tpm1 tropomyosin 1, alpha 9 C|9 40.0 cM 1423049 (probe) Tpm1
59046 Arpp19 cAMP-regulated phosphoprotein 19 9 E1 1450685 (probe) Arpp19
70769 Nolc1 nucleolar and coiled-body phosphoprotein 1 19 C3 1428870 (probe) Nolc1
13669 Eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 19 D 1448425 (probe) Eif3s10
94281 Sfxn4 sideroflexin 4 19 D3 1418873 (probe) Sfxn4
1455072 (probe) cDNA
26374 Rfwd2 ring finger and WD repeat domain 2 1 C3 1426912 (probe) Cop1
64659 Mrps14 mitochondrial ribosomal protein S14 1 H2.1 1420489 (probe) Mrps14
56752 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 1 H2 1437388 (probe) Aldh9a1
1448630 (probe) Sdhe
1429382 (probe) EST
226646 Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 1 H3 1451096 (probe) Ndufs2
1421096 (probe) Pdfn2
98193 Wdr42a WD repeat domain 42A 1 H3 1434133 (probe) D1Ucla4
98660 Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 1 H3|1 94.2 cM 1427465 (probe) Atp1a2
94332 Cadm3 cell adhesion molecule 3 1 H3 1418921 (probe) Necl1
15950 Ifi203 interferon activated gene 203 1 H3|1 95.31 cM 1448775 (probe) Ifi203
13849 Ephx1 epoxide hydrolase 1, microsomal 1 H4|1 98.5 cM 1422438 (probe) Ephx1
17684 Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 10 A2 1417129 (probe) Mrg1
56357 Ivd isovaleryl coenzyme A dehydrogenase - 1418238 (probe) Ivd
1428196 (probe) cDNA
228550 Itpka inositol 1,4,5-trisphosphate 3-kinase A 2 E5 1424037 (probe) Itpka
1451469 (probe) cDNA
1427570 (probe) cDNA
1427437 (probe) 1427437
84004 Mcam melanoma cell adhesion molecule 9 A5.1 1416357 (probe) Mcam
12282 Hyou1 hypoxia up-regulated 1 9 B 1423290 (probe) Cab140
1424468 (probe) cDNA
1417474 (probe) cDNA
14148 Fdx1 ferredoxin 1 9 B 1449108 (probe) Fdx1
24044 Scamp2 secretory carrier membrane protein 2 9 B 1448404 (probe) Scamp2
22003 Tpm1 tropomyosin 1, alpha 9 C|9 40.0 cM 1423721 (probe) Tpm1
1426556 (probe) cDNA
50772 Mapk6 mitogen-activated protein kinase 6 9 D|9 38.0 cM 1419169 (probe) Mapk6
20249 Scd1 stearoyl-Coenzyme A desaturase 1 19 C3|19 43.0 cM 1415964 (probe) Scd1
1449202 (probe) Scma4g
1425680 (probe) Btre
57344 As3mt arsenic (+3 oxidation state) methyltransferase 19 D1 1431980 (probe) Cyt19
226180 Ina internexin neuronal intermediate filament protein, alpha 19 C3 1448991 (probe) Ina
226180 Ina internexin neuronal intermediate filament protein, alpha 19 C3 1418178 (probe) Ina
14873 Gsto1 glutathione S-transferase omega 1 19 D1 1456036 (probe) Gsto1
1425111 (probe) cDNA
170750 Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 19 D2 1422443 (probe) Xpnpep1
1434162 (probe) cDNA
11757 Prdx3 peroxiredoxin 3 19 D3|19 50.0 cM 1416292 (probe) Prdx3
17926 Myoc myocilin 1 H2.1|1 83.6 cM 94122 (probe) Myoc
18986 Pou2f1 POU domain, class 2, transcription factor 1 1 H2.3|1 87.2 cM 102894 (probe) Pou2f1
66447 Mgst3 microsomal glutathione S-transferase 3 1 H2 96258 (probe) Mgst3
56752 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 1 H2 96243 (probe) Aldh9a1
66052 Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein 1 H3 94216 (probe) Sdhc
16524 Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 1 H3|1 94.2 cM 98332 (probe) Kcnj9
13349 Darc Duffy blood group, chemokine receptor 1 H3|1 94.0 cM 93412 (probe) Dfy
27058 Srp9 signal recognition particle 9 1 H5 101579 (probe) Srp9
12509 Cd59a CD59a antigen 2 55.0 cM 101516 (probe) Cd59a
20394 Scg5 secretogranin V 2 E5|2 64.0 cM 100131 (probe) Sgne1
17025 Alad aminolevulinate, delta-, dehydratase 4 B3|4 30.6 cM 101044 (probe) Alad
20660 Sorl1 sortilin-related receptor, LDLR class A repeats-containing - 100888 (probe) Sorl1
235293 Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) 9 B 102769 (probe) Sc5d
27965 Spg21 spastic paraplegia 21 homolog (human) 9 C|9 40.0 cM 95430 (probe) D9Wsu18e
59046 Arpp19 cAMP-regulated phosphoprotein 19 9 E1 97260 (probe) Arpp19
16579 Kifap3 kinesin-associated protein 3 1 H1 100113 (probe) Kifap3
433375 Creg1 cellular repressor of E1A-stimulated genes 1 1 H2.3 160502 (probe) Creg
96854 (probe) EST
97254 (probe) Rbm8
97197 (probe) EST
19672 Rcn1 reticulocalbin 1 2 E3|2 58.0 cM 160896 (probe) Rcn
96068 (probe) cDNA
56357 Ivd isovaleryl coenzyme A dehydrogenase - 104153 (probe) Ivd
160730 (probe) cDNA
17475 Mpdz multiple PDZ domain protein 4 C3|4 38.6 cM 93887 (probe) Mpdz
30959 Ddx25 DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 9 A3-A5 92678 (probe) Ddx25
97423 (probe) cDNA
100116 (probe) cDNA
20249 Scd1 stearoyl-Coenzyme A desaturase 1 19 C3|19 43.0 cM 94057 (probe) Scd1
160790 (probe) Btre
99162 (probe) EST
56392 Shoc2 soc-2 (suppressor of clear) homolog (C. elegans) 19 D2 104216 (probe) Shoc2
103574 (probe) EST
11757 Prdx3 peroxiredoxin 3 19 D3|19 50.0 cM 96256 (probe) Prdx3

GeneID	Symbol	Name	Genetic location	Original ID1	Original ID2
15939	Ier5	immediate early response 5	1 G3\|1 81.5 cM	1460009 (probe)	Ier5
14455	Gas5	growth arrest specific 5	1 H2.1	1449410 (probe)	Gas5
17926	Myoc	myocilin	1 H2.1\|1 83.6 cM	1450468 (probe)	Myoc
16579	Kifap3	kinesin-associated protein 3	1 H1	1451783 (probe)	Kifap3
				1419716 (probe)	Pou2fl
66447	Mgst3	microsomal glutathione S-transferase 3	1 H2	1448300 (probe)	Mgst3
56009	Refbp2	RNA and export factor binding protein 2	1 H3	1422993 (probe)	Refbp2
12847	Copa	coatomer protein complex subunit alpha	1 H3\|1 93.5 cM	1415706 (probe)	Copa
				1434893 (probe)	EST
				1455136 (probe)	EST
16524	Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	1 H3\|1 94.2 cM	1426115 (probe)	Kcnj9
				1419601 (probe)	Kenj10
13349	Darc	Duffy blood group, chemokine receptor	1 H3\|1 94.0 cM	1432273 (probe)	Dfy
226695	Ifi205	interferon activated gene 205	1 H3\|1 95.3 cM	1426906 (probe)	Ifi205
54418	Fmn2	formin 2	1 H3\|1 96.0 cM	1431725 (probe)	Fmn2
				1423871 (probe)	EST
				1453018 (probe)	cDNA
				1429763 (probe)	cDNA
12509	Cd59a	CD59a antigen	2 55.0 cM	1429830 (probe)	Cd59a
20394	Scg5	secretogranin V	2 E5\|2 64.0 cM	1423150 (probe)	Sgne1
				1425343 (probe)	cDNA
17025	Alad	aminolevulinate, delta-, dehydratase	4 B3\|4 30.6 cM	1424877 (probe)	Alad
17475	Mpdz	multiple PDZ domain protein	4 C3\|4 38.6 cM	1418664 (probe)	Mpdz
				1428760 (probe)	cDNA
20104	Rps6	ribosomal protein S6	4 C3	1416142 (probe)	Rps6
230379	Asah3l	N-acylsphingosine amidohydrolase 3-like	4 C4	1451355 (probe)	CRG-L1
				1450967 (probe)	cDNA
				1448250 (probe)	cDNA
20660	Sorl1	sortilin-related receptor, LDLR class A repeats-containing	-	1426258 (probe)	Sorl1
235293	Sc5d	sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)	9 B	1451457 (probe)	Sc5d
17967	Ncam1	neural cell adhesion molecule 1	9 A5.3\|9 28.0 cM	1426865 (probe)	Ncam1
12955	Cryab	crystallin, alpha B	9 A5.3\|9 29.0 cM	1416455 (probe)	Cryab
				1417211 (probe)	cDNA
				1448845 (probe)	EST
22003	Tpm1	tropomyosin 1, alpha	9 C\|9 40.0 cM	1423049 (probe)	Tpm1
59046	Arpp19	cAMP-regulated phosphoprotein 19	9 E1	1450685 (probe)	Arpp19
70769	Nolc1	nucleolar and coiled-body phosphoprotein 1	19 C3	1428870 (probe)	Nolc1
13669	Eif3s10	eukaryotic translation initiation factor 3, subunit 10 (theta)	19 D	1448425 (probe)	Eif3s10
94281	Sfxn4	sideroflexin 4	19 D3	1418873 (probe)	Sfxn4
				1455072 (probe)	cDNA
26374	Rfwd2	ring finger and WD repeat domain 2	1 C3	1426912 (probe)	Cop1
64659	Mrps14	mitochondrial ribosomal protein S14	1 H2.1	1420489 (probe)	Mrps14
56752	Aldh9a1	aldehyde dehydrogenase 9, subfamily A1	1 H2	1437388 (probe)	Aldh9a1
				1448630 (probe)	Sdhe
				1429382 (probe)	EST
226646	Ndufs2	NADH dehydrogenase (ubiquinone) Fe-S protein 2	1 H3	1451096 (probe)	Ndufs2
				1421096 (probe)	Pdfn2
98193	Wdr42a	WD repeat domain 42A	1 H3	1434133 (probe)	D1Ucla4
98660	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1 H3\|1 94.2 cM	1427465 (probe)	Atp1a2
94332	Cadm3	cell adhesion molecule 3	1 H3	1418921 (probe)	Necl1
15950	Ifi203	interferon activated gene 203	1 H3\|1 95.31 cM	1448775 (probe)	Ifi203
13849	Ephx1	epoxide hydrolase 1, microsomal	1 H4\|1 98.5 cM	1422438 (probe)	Ephx1
17684	Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	10 A2	1417129 (probe)	Mrg1
56357	Ivd	isovaleryl coenzyme A dehydrogenase	-	1418238 (probe)	Ivd
				1428196 (probe)	cDNA
228550	Itpka	inositol 1,4,5-trisphosphate 3-kinase A	2 E5	1424037 (probe)	Itpka
				1451469 (probe)	cDNA
				1427570 (probe)	cDNA
				1427437 (probe)	1427437
84004	Mcam	melanoma cell adhesion molecule	9 A5.1	1416357 (probe)	Mcam
12282	Hyou1	hypoxia up-regulated 1	9 B	1423290 (probe)	Cab140
				1424468 (probe)	cDNA
				1417474 (probe)	cDNA
14148	Fdx1	ferredoxin 1	9 B	1449108 (probe)	Fdx1
24044	Scamp2	secretory carrier membrane protein 2	9 B	1448404 (probe)	Scamp2
22003	Tpm1	tropomyosin 1, alpha	9 C\|9 40.0 cM	1423721 (probe)	Tpm1
				1426556 (probe)	cDNA
50772	Mapk6	mitogen-activated protein kinase 6	9 D\|9 38.0 cM	1419169 (probe)	Mapk6
20249	Scd1	stearoyl-Coenzyme A desaturase 1	19 C3\|19 43.0 cM	1415964 (probe)	Scd1
				1449202 (probe)	Scma4g
				1425680 (probe)	Btre
57344	As3mt	arsenic (+3 oxidation state) methyltransferase	19 D1	1431980 (probe)	Cyt19
226180	Ina	internexin neuronal intermediate filament protein, alpha	19 C3	1448991 (probe)	Ina
226180	Ina	internexin neuronal intermediate filament protein, alpha	19 C3	1418178 (probe)	Ina
14873	Gsto1	glutathione S-transferase omega 1	19 D1	1456036 (probe)	Gsto1
				1425111 (probe)	cDNA
170750	Xpnpep1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	19 D2	1422443 (probe)	Xpnpep1
				1434162 (probe)	cDNA
11757	Prdx3	peroxiredoxin 3	19 D3\|19 50.0 cM	1416292 (probe)	Prdx3
17926	Myoc	myocilin	1 H2.1\|1 83.6 cM	94122 (probe)	Myoc
18986	Pou2f1	POU domain, class 2, transcription factor 1	1 H2.3\|1 87.2 cM	102894 (probe)	Pou2f1
66447	Mgst3	microsomal glutathione S-transferase 3	1 H2	96258 (probe)	Mgst3
56752	Aldh9a1	aldehyde dehydrogenase 9, subfamily A1	1 H2	96243 (probe)	Aldh9a1
66052	Sdhc	succinate dehydrogenase complex, subunit C, integral membrane protein	1 H3	94216 (probe)	Sdhc
16524	Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	1 H3\|1 94.2 cM	98332 (probe)	Kcnj9
13349	Darc	Duffy blood group, chemokine receptor	1 H3\|1 94.0 cM	93412 (probe)	Dfy
27058	Srp9	signal recognition particle 9	1 H5	101579 (probe)	Srp9
12509	Cd59a	CD59a antigen	2 55.0 cM	101516 (probe)	Cd59a
20394	Scg5	secretogranin V	2 E5\|2 64.0 cM	100131 (probe)	Sgne1
17025	Alad	aminolevulinate, delta-, dehydratase	4 B3\|4 30.6 cM	101044 (probe)	Alad
20660	Sorl1	sortilin-related receptor, LDLR class A repeats-containing	-	100888 (probe)	Sorl1
235293	Sc5d	sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)	9 B	102769 (probe)	Sc5d
27965	Spg21	spastic paraplegia 21 homolog (human)	9 C\|9 40.0 cM	95430 (probe)	D9Wsu18e
59046	Arpp19	cAMP-regulated phosphoprotein 19	9 E1	97260 (probe)	Arpp19
16579	Kifap3	kinesin-associated protein 3	1 H1	100113 (probe)	Kifap3
433375	Creg1	cellular repressor of E1A-stimulated genes 1	1 H2.3	160502 (probe)	Creg
				96854 (probe)	EST
				97254 (probe)	Rbm8
				97197 (probe)	EST
19672	Rcn1	reticulocalbin 1	2 E3\|2 58.0 cM	160896 (probe)	Rcn
				96068 (probe)	cDNA
56357	Ivd	isovaleryl coenzyme A dehydrogenase	-	104153 (probe)	Ivd
				160730 (probe)	cDNA
17475	Mpdz	multiple PDZ domain protein	4 C3\|4 38.6 cM	93887 (probe)	Mpdz
30959	Ddx25	DEAD (Asp-Glu-Ala-Asp) box polypeptide 25	9 A3-A5	92678 (probe)	Ddx25
				97423 (probe)	cDNA
				100116 (probe)	cDNA
20249	Scd1	stearoyl-Coenzyme A desaturase 1	19 C3\|19 43.0 cM	94057 (probe)	Scd1
				160790 (probe)	Btre
				99162 (probe)	EST
56392	Shoc2	soc-2 (suppressor of clear) homolog (C. elegans)	19 D2	104216 (probe)	Shoc2
				103574 (probe)	EST
11757	Prdx3	peroxiredoxin 3	19 D3\|19 50.0 cM	96256 (probe)	Prdx3