| Gene Information |
| Gene ID: | | 20249 |
| Symbol: | | Scd1 |
| Full Name: | | stearoyl-Coenzyme A desaturase 1 |
| Alias: | | AA589638|AI265570|SCD|Scd-1|ab |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 19 |
| Genetic Location: | | 19 C3|19 43.0 cM |
| Physical Location: | | 44468944-44482042 on NC_000085.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 1415964 (probe) | | Original ID2: | | Scd1 | | Fold Change: | | 1.15 | | P Value: | | 3.00E-06 | | Note: | | Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:0.6 |
| | Gene Information | | Original ID1: | | 94057 (probe) | | Original ID2: | | Scd1 | | Fold Change: | | 1.24 | | P Value: | | 6.40E-05 | | Note: | | Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:0.8 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
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| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Calw2/Alcdp2 | Chronic Alcohol Withdrawal | 19 | 47 | 36.5-ter (cM) | 5.3 | 6.00E-07 | Significant | PARC |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0004768 | stearoyl-CoA 9-desaturase activity | Molecular Function | IEA | |
| GO:0016491 | oxidoreductase activity | Molecular Function | IEA | |
| GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | Molecular Function | IEA | |
| GO:0005506 | iron ion binding | Molecular Function | IEA | |
| GO:0006633 | fatty acid biosynthetic process | Biological Process | IMP (12815040) | |
| GO:0006629 | lipid metabolic process | Biological Process | IEA | |
| GO:0008610 | lipid biosynthetic process | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 20249 |
| MGI: | |
| Ensembl: | | ENSMUSG00000037071 |
| dbSNP: | | Scd1 |
| AceView: | | Scd1 |
