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Gene Information
Gene ID:20249
Symbol:Scd1
Full Name:stearoyl-Coenzyme A desaturase 1
Alias:AA589638|AI265570|SCD|Scd-1|ab
Organism:Mus musculus (Mouse)
Chromosome:19
Genetic Location:19 C3|19 43.0 cM
Physical Location:44468944-44482042 on NC_000085.5, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1415964 (probe)
Original ID2:Scd1
Fold Change:1.15
P Value:3.00E-06
Note:Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:0.6
Gene Information
Original ID1:94057 (probe)
Original ID2:Scd1
Fold Change:1.24
P Value:6.40E-05
Note:Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:0.8
Dataset Information
Name:15597075
Method:Microarray and QTL
Tissue:Brain
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Calw2/Alcdp2Chronic Alcohol Withdrawal194736.5-ter (cM)5.36.00E-07SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009127.3NP_033153.2NC_000085.5 range: 44468944..44482042, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0004768stearoyl-CoA 9-desaturase activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0016717oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of waterMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0006633fatty acid biosynthetic processBiological ProcessIMP (12815040)
GO:0006629lipid metabolic processBiological ProcessIEA
GO:0008610lipid biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:20249
MGI:
Ensembl:ENSMUSG00000037071
dbSNP:Scd1
AceView:Scd1