ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddx25

Full Name:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 25

Alias:

AW047046|GRTH

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 A3-A5

Physical Location:

35349409-35366048 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 29118 Symbol (Name): DDX25 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 25)

Ortholog Status:

The human GeneID 29118 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		92678 (probe)
Original ID2:		Ddx25
Fold Change:		1.74
P Value:		2.60E-05
Note:		Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:5.8

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013932.4	NP_038960.2	NC_000075.5 range: 35349409..35366048, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15096601\|16968703)
GO:0033391	chromatoid body	Cellular Component	IDA (15096601)
GO:0005737	cytoplasm	Cellular Component	IDA (15096601\|16968703)
GO:0008026	ATP-dependent helicase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (10608860)
GO:0004386	helicase activity	Molecular Function	IEA
GO:0004004	ATP-dependent RNA helicase activity	Molecular Function	IDA (10608860)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0007286	spermatid development	Biological Process	IDA (15096601)
GO:0007283	spermatogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006417	regulation of translation	Biological Process	IDA (16968703)
GO:0006406	mRNA export from nucleus	Biological Process	IDA (16968703)
GO:0051028	mRNA transport	Biological Process	IEA