| Gene Information |
| Gene ID: | | 19672 |
| Symbol: | | Rcn1 |
| Full Name: | | reticulocalbin 1 |
| Alias: | | Rcn |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 2 |
| Genetic Location: | | 2 E3|2 58.0 cM |
| Physical Location: | | 105226104-105239475 on NC_000068.6, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 5954 Symbol (Name): RCN1 (reticulocalbin 1, EF-hand calcium binding domain) |
| Ortholog Status: | | The human GeneID 5954 is not in current human dataset. |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 160896 (probe) | | Original ID2: | | Rcn | | Fold Change: | | 1.44 | | P Value: | | 5.40E-07 | | Note: | | Moderate priority differential expression on U74Av2 array. Direction: D2>B6; Cis LOD:0.8 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
|
|
| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Etact1 | Alcohol Stimulated Activity | 2 | 51 | 41-61 (cM) | 3.9 | 2.20E-05 | Significant | PARC |
|
|
| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005615 | extracellular space | Cellular Component | RCA (12466851) | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IEA | |
| GO:0005509 | calcium ion binding | Molecular Function | IEA | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 19672 |
| MGI: | |
| Ensembl: | | ENSMUSG00000005973 |
| dbSNP: | | Rcn1 |
| AceView: | | Rcn1 |
