| Gene Information |
| Gene ID: | | 13849 |
| Symbol: | | Ephx1 |
| Full Name: | | epoxide hydrolase 1, microsomal |
| Alias: | | AI195553|Eph-1|Eph1 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 H4|1 98.5 cM |
| Physical Location: | | 182919686-182947625 on NC_000067.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 2052 Symbol (Name): EPHX1 (epoxide hydrolase 1, microsomal (xenobiotic)) |
| Ortholog Status: | | The human GeneID 2052 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 1422438 (probe) | | Original ID2: | | Ephx1 | | Fold Change: | | 1.17 | | P Value: | | 4.20E-05 | | Note: | | Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:6.3 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
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| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Calw1/Alcdp1 | Chronic Alcohol Withdrawal | 1 | 96 | 89-106.3 (cM) | 7.6 | 2.00E-09 | Significant | PARC |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005615 | extracellular space | Cellular Component | RCA (12466851) | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IEA | |
| GO:0005792 | microsome | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0003824 | catalytic activity | Molecular Function | IEA | |
| GO:0016787 | hydrolase activity | Molecular Function | IEA | |
| GO:0033961 | cis-stilbene-oxide hydrolase activity | Molecular Function | IEA | |
| GO:0004301 | epoxide hydrolase activity | Molecular Function | IEA | |
| GO:0006805 | xenobiotic metabolic process | Biological Process | IEA | |
| GO:0019439 | aromatic compound catabolic process | Biological Process | IEA | |
| GO:0009636 | response to toxin | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 13849 |
| MGI: | |
| Ensembl: | | ENSMUSG00000038776 |
| dbSNP: | | Ephx1 |
| AceView: | | Ephx1 |
