ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

EPHX1

Full Name:

epoxide hydrolase 1, microsomal (xenobiotic)

Alias:

EPHX|EPOX|MEH

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q42.1

Physical Location:

224079598-224099883 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13849 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		J03518
Fold Change:		-1.4, -1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:		L25879
Fold Change:		2.52

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

EPHX1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000120.2	NP_000111.1	NC_000001.9 range: 224079598..224099883

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0004301	epoxide hydrolase activity	Molecular Function	TAS (7516776)
GO:0033961	cis-stilbene-oxide hydrolase activity	Molecular Function	IEA
GO:0009636	response to toxin	Biological Process	IEA
GO:0006805	xenobiotic metabolic process	Biological Process	IEA
GO:0019439	aromatic compound catabolic process	Biological Process	IEA