ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sdhc

Full Name:

succinate dehydrogenase complex, subunit C, integral membrane protein

Alias:

0610010E03Rik|AI316496|AU019277|MGC103103

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H3

Physical Location:

173059295-173080732 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6391 Symbol (Name): SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa)

Ortholog Status:

The human GeneID 6391 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		94216 (probe)
Original ID2:		Sdhc
Fold Change:		1.37
P Value:		2.80E-04
Note:		Highest priority differential expression on U74Av2 array. Direction: D2>B6; Cis LOD:0.3

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025321.2	NP_079597.1	NC_000067.5 range: 173059295..173080732, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853\|16120479)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0000104	succinate dehydrogenase activity	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006099	tricarboxylic acid cycle	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA