ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ivd

Full Name:

isovaleryl coenzyme A dehydrogenase

Alias:

1300016K07Rik|6720455E18Rik|AI463340

Organism:

Mus musculus (Mouse)

Chromosome:

Physical Location:

118687735-118707092 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3712 Symbol (Name): IVD (isovaleryl Coenzyme A dehydrogenase)

Ortholog Status:

The human GeneID 3712 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1418238 (probe)
Original ID2:		Ivd
Fold Change:		1.15
P Value:		2.60E-04
Note:		Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:14.7

Gene Information

Original ID1:		104153 (probe)
Original ID2:		Ivd
Fold Change:		1.21
P Value:		1.00E-04
Note:		Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:4.5

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019826.3	NP_062800.1	NC_000068.6 range: 118687735..118707092

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005739	mitochondrion	Cellular Component	RCA (12466851)
GO:0003995	acyl-CoA dehydrogenase activity	Molecular Function	IEA
GO:0008470	isovaleryl-CoA dehydrogenase activity	Molecular Function	RCA (12466851)
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	RCA (12466851)
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	Molecular Function	IEA
GO:0050660	FAD binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA