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Gene Information
Gene ID:56357
Full Name:isovaleryl coenzyme A dehydrogenase
Organism:Mus musculus (Mouse)
Physical Location:118687735-118707092 on NC_000068.6
Gene Type:protein-coding
Human Ortholog:GeneID: 3712    Symbol (Name): IVD (isovaleryl Coenzyme A dehydrogenase)
Ortholog Status:The human GeneID 3712 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1418238 (probe)
Original ID2:Ivd
Fold Change:1.15
P Value:2.60E-04
Note:Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:14.7
Gene Information
Original ID1:104153 (probe)
Original ID2:Ivd
Fold Change:1.21
P Value:1.00E-04
Note:Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:4.5
Dataset Information
Method:Microarray and QTL
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019826.3NP_062800.1NC_000068.6 range: 118687735..118707092
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0005739mitochondrionCellular ComponentRCA (12466851)
GO:0003995acyl-CoA dehydrogenase activityMolecular FunctionIEA
GO:0008470isovaleryl-CoA dehydrogenase activityMolecular FunctionRCA (12466851)
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionRCA (12466851)
GO:0016627oxidoreductase activity, acting on the CH-CH group of donorsMolecular FunctionIEA
GO:0050660FAD bindingMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:56357