ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rps6

Full Name:

ribosomal protein S6

Alias:

MGC102571|MGC103209

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C3

Physical Location:

86500002-86503270 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6194 Symbol (Name): RPS6 (ribosomal protein S6)

Ortholog Status:

The human GeneID 6194 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1416142 (probe)
Original ID2:		Rps6
Fold Change:		1.35
P Value:		1.60E-08
Note:		Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:21.5

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009096.3	NP_033122.1	NC_000070.5 range: 86500002..86503270, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (16286931)
GO:0030529	ribonucleoprotein complex	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	RCA (12466851)
GO:0005737	cytoplasm	Cellular Component	IDA (12388085)
GO:0005840	ribosome	Cellular Component	RCA (12466851)
GO:0022627	cytosolic small ribosomal subunit	Cellular Component	RCA (12466851)
GO:0003723	RNA binding	Molecular Function	RCA (12466851)
GO:0003735	structural constituent of ribosome	Molecular Function	RCA (12466851)
GO:0042593	glucose homeostasis	Biological Process	IDA (16166381)
GO:0006412	translation	Biological Process	RCA (12466851)