ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fmn2

Full Name:

formin 2

Alias:

AU024104

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H3|1 96.0 cM

Physical Location:

176419302-176752207 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 56776 Symbol (Name): FMN2 (formin 2)

Ortholog Status:

The human GeneID 56776 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1431725 (probe)
Original ID2:		Fmn2
Fold Change:		1.34
P Value:		2.00E-07
Note:		Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:1.3

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

QTL Information

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019445.2	NP_062318.2	NC_000067.5 range: 176419302..176752207

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0015629	actin cytoskeleton	Cellular Component	IEA
GO:0003779	actin binding	Molecular Function	IEA
GO:0048477	oogenesis	Biological Process	IMP (12447394)
GO:0040038	polar body extrusion after meiotic divisions	Biological Process	IMP (12447394)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IEA
GO:0016344	meiotic chromosome movement towards spindle pole	Biological Process	IMP (12447394)
GO:0016043	cellular component organization and biogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007132	meiotic metaphase I	Biological Process	IMP (12447394)
GO:0051295	establishment of meiotic spindle localization	Biological Process	IMP (12447394)