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Gene Information
Gene ID:12509
Full Name:CD59a antigen
Organism:Mus musculus (Mouse)
Genetic Location:2 55.0 cM
Physical Location:103936009-103955505 on NC_000068.6
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1429830 (probe)
Original ID2:Cd59a
Fold Change:1.25
P Value:2.80E-05
Note:Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:1.5
Gene Information
Original ID1:101516 (probe)
Original ID2:Cd59a
Fold Change:1.7
P Value:1.10E-06
Note:Highest priority differential expression on U74Av2 array. Direction: D2>B6; Cis LOD:0.2
Dataset Information
Method:Microarray and QTL
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Etact1Alcohol Stimulated Activity25141-61 (cM)3.92.20E-05SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007652.4NP_031678.1NC_000068.6 range: 103936009..103955505
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIEA
GO:0031225anchored to membraneCellular ComponentIEA
Other Database Cross Links
NCBI Entrez Gene:12509