ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Asah3l

Full Name:

N-acylsphingosine amidohydrolase 3-like

Alias:

2410116I05Rik|Acer2|CRG-L1|maCER2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C4

Physical Location:

86520367-86566778 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 340485 Symbol (Name): ASAH3L (N-acylsphingosine amidohydrolase 3-like)

Ortholog Status:

The human GeneID 340485 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1451355 (probe)
Original ID2:		CRG-L1
Fold Change:		1.27
P Value:		2.20E-07
Note:		Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:7.4

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_139306.1	NP_647467.1	NC_000070.5 range: 86520367..86566778

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Molecular Function	IEA
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006672	ceramide metabolic process	Biological Process	IEA