ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sfxn4

Full Name:

sideroflexin 4

Alias:

MGC107253

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 D3

Physical Location:

60914663-60937314 on NC_000085.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 119559 Symbol (Name): SFXN4 (sideroflexin 4)

Ortholog Status:

The human GeneID 119559 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1418873 (probe)
Original ID2:		Sfxn4
Fold Change:		1.27
P Value:		5.00E-07
Note:		Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:10.3

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053198.2	NP_444428.2	NC_000085.5 range: 60914663..60937314, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005739	mitochondrion	Cellular Component	ISS (11274051)
GO:0016020	membrane	Cellular Component	RCA (12466851)
GO:0008324	cation transmembrane transporter activity	Molecular Function	RCA (12466851)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0006826	iron ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006812	cation transport	Biological Process	RCA (12466851)