ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pou2f1

Full Name:

POU domain, class 2, transcription factor 1

Alias:

2810482H01Rik|Oct-1|Otf-1|Otf1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H2.3|1 87.2 cM

Physical Location:

167805602-167932764 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5451 Symbol (Name): POU2F1 (POU class 2 homeobox 1)

Ortholog Status:

The human GeneID 5451 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		102894 (probe)
Original ID2:		Pou2f1
Fold Change:		1.99
P Value:		3.90E-07
Note:		Highest priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:4.9

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005667	transcription factor complex	Cellular Component	IDA (7969117)
GO:0005634	nucleus	Cellular Component	IDA (7969117\|8131747\|11937630\|15024082\|15613485)
GO:0005634	nucleus	Cellular Component	ISO
GO:0005634	nucleus	Cellular Component	ISS (11891224)
GO:0016563	transcription activator activity	Molecular Function	IDA (14729276)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (1690859\|7969117\|8131747\|8960364)
GO:0043565	sequence-specific DNA binding	Molecular Function	ISO
GO:0003677	DNA binding	Molecular Function	IDA (9738004\|11937630\|14729276\|15024082\|15613485)
GO:0005515	protein binding	Molecular Function	IPI (16002402)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0030528	transcription regulator activity	Molecular Function	ISS (11891224)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0016481	negative regulation of transcription	Biological Process	ISS (11891224)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (14729276\|16002402)