ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POU2F1

Full Name:

POU class 2 homeobox 1

Alias:

OCT1|OTF1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q22-q23

Physical Location:

165456766-165651965 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18986 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D1S2878

163669990

Region:		163669990-165871089
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002697.2	NP_002688.2	NC_000001.9 range: 165456766..165651965

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (9242494\|11891224)
GO:0003700	transcription factor activity	Molecular Function	TAS (2341156)
GO:0005515	protein binding	Molecular Function	IPI (10629049\|12670868)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (7945330\|9242494)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0016481	negative regulation of transcription	Biological Process	IDA (11891224)