| Gene Information |
| Gene ID: | | 12955 |
| Symbol: | | Cryab |
| Full Name: | | crystallin, alpha B |
| Alias: | | Crya-2|Crya2 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 9 |
| Genetic Location: | | 9 A5.3|9 29.0 cM |
| Physical Location: | | 50560862-50564737 on NC_000075.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 1410 Symbol (Name): CRYAB (crystallin, alpha B) |
| Ortholog Status: | | The human GeneID 1410 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 1416455 (probe) | | Original ID2: | | Cryab | | Fold Change: | | 1.33 | | P Value: | | 4.30E-06 | | Note: | | Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:0.1 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
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| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Ap5q | Alcohol Preference Drinking | 9 | 25 | 10-35 (cM) | 4.8 | | Significant | PARC |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0043292 | contractile fiber | Cellular Component | IDA (14627610) | |
| GO:0005625 | soluble fraction | Cellular Component | IDA (14627610) | |
| GO:0005626 | insoluble fraction | Cellular Component | IDA (14627610) | |
| GO:0005886 | plasma membrane | Cellular Component | IDA (14627610) | |
| GO:0030018 | Z disc | Cellular Component | IDA (14627610) | |
| GO:0005212 | structural constituent of eye lens | Molecular Function | TAS (12546709) | |
| GO:0009408 | response to heat | Biological Process | RCA (12466851) | |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | Biological Process | NAS (15609325) | |
| GO:0043010 | camera-type eye development | Biological Process | IGI (12546709) | |
| GO:0007517 | muscle development | Biological Process | IGI (11687538) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 12955 |
| MGI: | |
| Ensembl: | | ENSMUSG00000032060 |
| dbSNP: | | Cryab |
| AceView: | | Cryab |
