Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:12955
Symbol:Cryab
Full Name:crystallin, alpha B
Alias:Crya-2|Crya2
Organism:Mus musculus (Mouse)
Chromosome:9
Genetic Location:9 A5.3|9 29.0 cM
Physical Location:50560862-50564737 on NC_000075.5
Gene Type:protein-coding
Human Ortholog:GeneID: 1410    Symbol (Name): CRYAB (crystallin, alpha B)
Ortholog Status:The human GeneID 1410 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1416455 (probe)
Original ID2:Cryab
Fold Change:1.33
P Value:4.30E-06
Note:Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:0.1
Dataset Information
Name:15597075
Method:Microarray and QTL
Tissue:Brain
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Ap5qAlcohol Preference Drinking92510-35 (cM)4.8 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009964.2NP_034094.1NC_000075.5 range: 50560862..50564737
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043292contractile fiberCellular ComponentIDA (14627610)
GO:0005625soluble fractionCellular ComponentIDA (14627610)
GO:0005626insoluble fractionCellular ComponentIDA (14627610)
GO:0005886plasma membraneCellular ComponentIDA (14627610)
GO:0030018Z discCellular ComponentIDA (14627610)
GO:0005212structural constituent of eye lensMolecular FunctionTAS (12546709)
GO:0009408response to heatBiological ProcessRCA (12466851)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessNAS (15609325)
GO:0043010camera-type eye developmentBiological ProcessIGI (12546709)
GO:0007517muscle developmentBiological ProcessIGI (11687538)
Other Database Cross Links
NCBI Entrez Gene:12955
MGI:
Ensembl:ENSMUSG00000032060
dbSNP:Cryab
AceView:Cryab