ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CRYAB

Full Name:

crystallin, alpha B

Alias:

CRYA2|CTPP2|HSPB5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11q22.3-q23.1

Physical Location:

111284559-111287682 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12955 Rat: 25420 Fly: 37744 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AV733563

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:		AL038340
Fold Change:		2.65

Gene Information

Original ID1:		AL038340
Fold Change:		2.15

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Information

Original ID1:

CRYAB

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001885.1	NP_001876.1	NC_000011.8 range: 111284559..111287682, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NR
GO:0005737	cytoplasm	Cellular Component	IDA (14752512)
GO:0005212	structural constituent of eye lens	Molecular Function	IEA
GO:0051082	unfolded protein binding	Molecular Function	NR
GO:0006916	anti-apoptosis	Biological Process	IDA (14752512)
GO:0006457	protein folding	Biological Process	NAS (9731540)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	NAS (15609325)
GO:0007601	visual perception	Biological Process	NR
GO:0032387	negative regulation of intracellular transport	Biological Process	IDA (14752512)
GO:0006936	muscle contraction	Biological Process	TAS (9731540)