Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:1410
Symbol:CRYAB
Full Name:crystallin, alpha B
Alias:CRYA2|CTPP2|HSPB5
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11q22.3-q23.1
Physical Location:111284559-111287682 on NC_000011.8, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 12955 Rat: 25420 Fly: 37744 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AV733563
Dataset Information
Name:12065639
Method:Microarray
Tissue:Frontal and motor cortices
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.
Gene Information
Original ID1:AL038340
Fold Change:2.65
Gene Information
Original ID1:AL038340
Fold Change:2.15
Dataset Information
Name:15236863
Method:Microarray
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Information
Original ID1:CRYAB
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001885.1NP_001876.1NC_000011.8 range: 111284559..111287682, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNR
GO:0005737cytoplasmCellular ComponentIDA (14752512)
GO:0005212structural constituent of eye lensMolecular FunctionIEA
GO:0051082unfolded protein bindingMolecular FunctionNR
GO:0006916anti-apoptosisBiological ProcessIDA (14752512)
GO:0006457protein foldingBiological ProcessNAS (9731540)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessNAS (15609325)
GO:0007601visual perceptionBiological ProcessNR
GO:0032387negative regulation of intracellular transportBiological ProcessIDA (14752512)
GO:0006936muscle contractionBiological ProcessTAS (9731540)
Other Database Cross Links
NCBI Entrez Gene:1410
HGNC:2389
Ensembl:ENSG00000109846
MIM:123590
HPRD:00428
HuGE Navigator:1410
dbSNP:CRYAB
GeneCard:CRYAB
AceView:CRYAB