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Gene Information
Gene ID:25420
Full Name:crystallin, alpha B
Organism:Rattus norvegicus (Rat)
Genetic Location:8q23
Physical Location:54107252-54111504 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1410    Symbol (Name): CRYAB (crystallin, alpha B)
Ortholog Status:The human GeneID 1410 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cryab
Fold Change:1.35
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012935.3NP_037067.1NC_005107.2 range: 54107252..54111504
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043292contractile fiberCellular ComponentISS
GO:0015630microtubule cytoskeletonCellular ComponentIDA (15075233)
GO:0030018Z discCellular ComponentISS
GO:0005886plasma membraneCellular ComponentISS
GO:0005794Golgi apparatusCellular ComponentIDA (15339919)
GO:0005737cytoplasmCellular ComponentISS
GO:0005626insoluble fractionCellular ComponentISS
GO:0005625soluble fractionCellular ComponentISS
GO:0032432actin filament bundleCellular ComponentIDA (10625651)
GO:0008092cytoskeletal protein bindingMolecular FunctionIDA (15075233)
GO:0008017microtubule bindingMolecular FunctionIDA (15075233)
GO:0005212structural constituent of eye lensMolecular FunctionIEA
GO:0005212structural constituent of eye lensMolecular FunctionTAS (2912453)
GO:0006950response to stressBiological ProcessIPI (11945023)
GO:0043066negative regulation of apoptosisBiological ProcessIMP (15358243)
GO:0043010camera-type eye developmentBiological ProcessISS
GO:0032387negative regulation of intracellular transportBiological ProcessISS
GO:0031109microtubule polymerization or depolymerizationBiological ProcessIMP (15075233)
GO:0006006glucose metabolic processBiological ProcessIMP (15358243)
GO:0006800oxygen and reactive oxygen species metabolic processBiological ProcessIMP (15358243)
GO:0006916anti-apoptosisBiological ProcessISS
GO:0007517muscle developmentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25420