ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cryab

Full Name:

crystallin, alpha B

Alias:

AACRYA

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q23

Physical Location:

54107252-54111504 on NC_005107.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1410 Symbol (Name): CRYAB (crystallin, alpha B)

Ortholog Status:

The human GeneID 1410 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012935.3	NP_037067.1	NC_005107.2 range: 54107252..54111504

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043292	contractile fiber	Cellular Component	ISS
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA (15075233)
GO:0030018	Z disc	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005794	Golgi apparatus	Cellular Component	IDA (15339919)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005626	insoluble fraction	Cellular Component	ISS
GO:0005625	soluble fraction	Cellular Component	ISS
GO:0032432	actin filament bundle	Cellular Component	IDA (10625651)
GO:0008092	cytoskeletal protein binding	Molecular Function	IDA (15075233)
GO:0008017	microtubule binding	Molecular Function	IDA (15075233)
GO:0005212	structural constituent of eye lens	Molecular Function	IEA
GO:0005212	structural constituent of eye lens	Molecular Function	TAS (2912453)
GO:0006950	response to stress	Biological Process	IPI (11945023)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (15358243)
GO:0043010	camera-type eye development	Biological Process	ISS
GO:0032387	negative regulation of intracellular transport	Biological Process	ISS
GO:0031109	microtubule polymerization or depolymerization	Biological Process	IMP (15075233)
GO:0006006	glucose metabolic process	Biological Process	IMP (15358243)
GO:0006800	oxygen and reactive oxygen species metabolic process	Biological Process	IMP (15358243)
GO:0006916	anti-apoptosis	Biological Process	ISS
GO:0007517	muscle development	Biological Process	ISS