| Gene Information |
| Gene ID: | | 16579 |
| Symbol: | | Kifap3 |
| Full Name: | | kinesin-associated protein 3 |
| Alias: | | KAP3|SMAP |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 H1 |
| Physical Location: | | 165709809-165847230 on NC_000067.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 22920 Symbol (Name): KIFAP3 (kinesin-associated protein 3) |
| Ortholog Status: | | The human GeneID 22920 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | 1451783 (probe) | | Original ID2: | | Kifap3 | | Fold Change: | | 1.27 | | P Value: | | 2.50E-06 | | Note: | | Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:7.8 |
| | Gene Information | | Original ID1: | | 100113 (probe) | | Original ID2: | | Kifap3 | | Fold Change: | | 1.42 | | P Value: | | 1.80E-04 | | Note: | | Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:2.6 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005871 | kinesin complex | Cellular Component | IEA | |
| GO:0016939 | kinesin II complex | Cellular Component | IPI (8710890) | |
| GO:0005083 | small GTPase regulator activity | Molecular Function | TAS (10793158) | |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | Molecular Function | TAS (10793158) | |
| GO:0005488 | binding | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | IPI (15834408) | |
| GO:0019894 | kinesin binding | Molecular Function | IEA | |
| GO:0008285 | negative regulation of cell proliferation | Biological Process | IMP (15834408) | |
| GO:0008104 | protein localization | Biological Process | IMP (15834408) | |
| GO:0007266 | Rho protein signal transduction | Biological Process | TAS (10793158) | |
| GO:0007017 | microtubule-based process | Biological Process | IPI (8710890) | |
| GO:0046587 | positive regulation of calcium-dependent cell-cell adhesion | Biological Process | IMP (15834408) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 16579 |
| MGI: | |
| Ensembl: | | ENSMUSG00000026585 |
| dbSNP: | | Kifap3 |
| AceView: | | Kifap3 |
