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Gene Information
Gene ID:11757
Symbol:Prdx3
Full Name:peroxiredoxin 3
Alias:AW822249|Aop1|D0Tohi1|Ef2l|Mer5|Prx3|SP22|TDXM
Organism:Mus musculus (Mouse)
Chromosome:19
Genetic Location:19 D3|19 50.0 cM
Physical Location:60939968-60950440 on NC_000085.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10935    Symbol (Name): PRDX3 (peroxiredoxin 3)
Ortholog Status:The human GeneID 10935 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1416292_at
Dataset Information
Name:16618939
Method:Microarray
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
Gene Information
Original ID1:1416292 (probe)
Original ID2:Prdx3
Fold Change:1.57
P Value:3.90E-07
Note:Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:10.8
Gene Information
Original ID1:96256 (probe)
Original ID2:Prdx3
Fold Change:1.26
P Value:4.70E-05
Note:Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:0.8
Dataset Information
Name:15597075
Method:Microarray and QTL
Tissue:Brain
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Calw2/Alcdp2Chronic Alcohol Withdrawal194736.5-ter (cM)5.36.00E-07SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007452.2NP_031478.1NC_000085.5 range: 60939968..60950440, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0004601peroxidase activityMolecular FunctionIEA
GO:0016209antioxidant activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0042802identical protein bindingMolecular FunctionIPI (11591653)
GO:0051920peroxiredoxin activityMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:11757
MGI:
Ensembl:ENSMUSG00000024997
dbSNP:Prdx3
AceView:Prdx3