ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ncam1

Full Name:

neural cell adhesion molecule 1

Alias:

CD56|E-NCAM|NCAM-1|Ncam

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 A5.3|9 28.0 cM

Physical Location:

49310242-49607173 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4684 Symbol (Name): NCAM1 (neural cell adhesion molecule 1)

Ortholog Status:

The human GeneID 4684 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

1426865_a_at

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Information

Original ID1:		1426865 (probe)
Original ID2:		Ncam1
Fold Change:		1.93
P Value:		2.50E-09
Note:		Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:1.5

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap5q	Alcohol Preference Drinking	9	25	10-35 (cM)	4.8		Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009897	external side of plasma membrane	Cellular Component	IDA (7613634)
GO:0031225	anchored to membrane	Cellular Component	IEA
GO:0030424	axon	Cellular Component	IDA (15964824)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005021	vascular endothelial growth factor receptor activity	Molecular Function	IEA
GO:0008201	heparin binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IDA (7613634)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0034109	homotypic cell-cell adhesion	Biological Process	IMP (7613634)
GO:0050850	positive regulation of calcium-mediated signaling	Biological Process	IDA (7613634)