| Gene Information |
| Gene ID: | | 15939 |
| Symbol: | | Ier5 |
| Full Name: | | immediate early response 5 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 G3|1 81.5 cM |
| Physical Location: | | 156944655-156946765 on NC_000067.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 51278 Symbol (Name): IER5 (immediate early response 5) |
| Ortholog Status: | | The human GeneID 51278 is not in current human dataset. |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | 16618939 | | Method: | | Microarray | | Tissue: | | Whole brain | | Phenotype: | | Alcohol preference | | Publication: | | Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed | | Summary: | | Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values. |
| | Gene Information | | Original ID1: | | 1460009 (probe) | | Original ID2: | | Ier5 | | Fold Change: | | 1.35 | | P Value: | | 1.80E-07 | | Note: | | Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:17.8 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
|
|
| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Ap1q | Alcohol Preference Drinking | 1 | 76 | 45-95 (cM) | 4.5 | | Significant | PARC |
|
|
| Gene Refseq Sequence Annotation |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 15939 |
| MGI: | |
| Ensembl: | | ENSMUSG00000056708 |
| dbSNP: | | Ier5 |
| AceView: | | Ier5 |
