ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mapk6

Full Name:

mitogen-activated protein kinase 6

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 D|9 38.0 cM

Physical Location:

75234707-75257820 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5597 Symbol (Name): MAPK6 (mitogen-activated protein kinase 6)

Ortholog Status:

The human GeneID 5597 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1419169 (probe)
Original ID2:		Mapk6
Fold Change:		1.1
P Value:		1.10E-04
Note:		Moderate priority differential expression on 430A array. Direction: D2>B6; Cis LOD:2.5

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (15538386)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15538386)
GO:0004707	MAP kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA