ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Xpnpep1

Full Name:

X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

Alias:

D230045I08Rik

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 D2

Physical Location:

53065672-53113031 on NC_000085.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7511 Symbol (Name): XPNPEP1 (X-prolyl aminopeptidase (aminopeptidase P) 1, soluble)

Ortholog Status:

The human GeneID 7511 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1422443 (probe)
Original ID2:		Xpnpep1
Fold Change:		1.17
P Value:		5.60E-05
Note:		Moderate priority differential expression on 430A array. Direction: D2>B6; Cis LOD:2.4

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133216.2	NP_573479.2	NC_000085.5 range: 53065672..53113031, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004177	aminopeptidase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008451	X-Pro aminopeptidase activity	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0008235	metalloexopeptidase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA