ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Itpka

Full Name:

inositol 1,4,5-trisphosphate 3-kinase A

Alias:

MGC28924

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 E5

Physical Location:

119568072-119576988 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3706 Symbol (Name): ITPKA (inositol 1,4,5-trisphosphate 3-kinase A)

Ortholog Status:

The human GeneID 3706 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		1424037 (probe)
Original ID2:		Itpka
Fold Change:		1.22
P Value:		2.40E-05
Note:		Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:3.1

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_146125.2	NP_666237.1	NC_000068.6 range: 119568072..119576988

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004428	inositol or phosphatidylinositol kinase activity	Molecular Function	TAS (10454357)
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0008440	inositol trisphosphate 3-kinase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006020	inositol metabolic process	Biological Process	IMP (10454357)