Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:12847
Symbol:Copa
Full Name:coatomer protein complex subunit alpha
Alias:AU040324|xenin
Organism:Mus musculus (Mouse)
Chromosome:1
Genetic Location:1 H3|1 93.5 cM
Physical Location:174012933-174052454 on NC_000067.5
Gene Type:protein-coding
Human Ortholog:GeneID: 1314    Symbol (Name): COPA (coatomer protein complex, subunit alpha)
Ortholog Status:The human GeneID 1314 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Copa
Dataset Information
Name:16618939
Method:Microarray
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
Gene Information
Original ID1:1415706 (probe)
Original ID2:Copa
Fold Change:1.23
P Value:2.40E-05
Note:Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:8
Dataset Information
Name:15597075
Method:Microarray and QTL
Tissue:Brain
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcw1Acute Alcohol Withdrawal196172.3-176.5 (Mb)5.63.00E-07SignificantPARC
Calw1/Alcdp1Chronic Alcohol Withdrawal19689-106.3 (cM)7.62.00E-09SignificantPARC
Ap1qAlcohol Preference Drinking17645-95 (cM)4.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009938.3NP_034068.2NC_000067.5 range: 174012933..174052454
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0019028viral capsidCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0005792microsomeCellular ComponentISO
GO:0005737cytoplasmCellular ComponentISO
GO:0005625soluble fractionCellular ComponentISO
GO:0005615extracellular spaceCellular ComponentISO
GO:0005576extracellular regionCellular ComponentIEA
GO:0030117membrane coatCellular ComponentIEA
GO:0030126COPI vesicle coatCellular ComponentISO
GO:0016020membraneCellular ComponentIEA
GO:0005179hormone activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0015031protein transportBiological ProcessIEA
GO:0006886intracellular protein transportBiological ProcessIEA
GO:0016192vesicle-mediated transportBiological ProcessIEA
GO:0030157pancreatic juice secretionBiological ProcessISO
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:12847
MGI:
Ensembl:ENSMUSG00000026553
dbSNP:Copa
AceView:Copa