| Gene Information |
| Gene ID: | | 16524 |
| Symbol: | | Kcnj9 |
| Full Name: | | potassium inwardly-rectifying channel, subfamily J, member 9 |
| Alias: | | 1700085N21Rik|Girk3|Kir3.3|mbGIRK3 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 H3|1 94.2 cM |
| Physical Location: | | 174251163-174259393 on NC_000067.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 3765 Symbol (Name): KCNJ9 (potassium inwardly-rectifying channel, subfamily J, member 9) |
| Ortholog Status: | | The human GeneID 3765 is not in current human dataset. |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | U11860 | | Note: | | Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains |
| | Dataset Information | | Name: | | 15282116 | | Method: | | Microarray | | Tissue: | | Striata | | Phenotype: | | Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration | | Publication: | | Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed | | Summary: | | Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By. |
| | Gene Information | | Original ID1: | | 1426115 (probe) | | Original ID2: | | Kcnj9 | | Fold Change: | | 1.55 | | P Value: | | 4.60E-07 | | Note: | | Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:7.6 |
| | Gene Information | | Original ID1: | | 98332 (probe) | | Original ID2: | | Kcnj9 | | Fold Change: | | 4.91 | | P Value: | | 2.70E-10 | | Note: | | Highest priority differential expression on U74Av2 array. Direction: D2>B6; Cis LOD:13.7 |
| | Dataset Information | | Name: | | 15597075 | | Method: | | Microarray and QTL | | Tissue: | | Brain | | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
|
|
| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Alcw1 | Acute Alcohol Withdrawal | 1 | 96 | 172.3-176.5 (Mb) | 5.6 | 3.00E-07 | Significant | PARC | | Calw1/Alcdp1 | Chronic Alcohol Withdrawal | 1 | 96 | 89-106.3 (cM) | 7.6 | 2.00E-09 | Significant | PARC | | Ap1q | Alcohol Preference Drinking | 1 | 76 | 45-95 (cM) | 4.5 | | Significant | PARC |
|
|
| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0016021 | integral to membrane | Cellular Component | RCA (12466851) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0005216 | ion channel activity | Molecular Function | IEA | |
| GO:0015467 | G-protein activated inward rectifier potassium channel activity | Molecular Function | IEA | |
| GO:0030955 | potassium ion binding | Molecular Function | IEA | |
| GO:0005244 | voltage-gated ion channel activity | Molecular Function | IEA | |
| GO:0005242 | inward rectifier potassium channel activity | Molecular Function | IEA | |
| GO:0006811 | ion transport | Biological Process | IEA | |
| GO:0006810 | transport | Biological Process | IEA | |
| GO:0006813 | potassium ion transport | Biological Process | IEA | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 16524 |
| MGI: | |
| Ensembl: | | ENSMUSG00000038026 |
| dbSNP: | | Kcnj9 |
| AceView: | | Kcnj9 |
