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Gene Information
Gene ID:22003
Symbol:Tpm1
Full Name:tropomyosin 1, alpha
Alias:AA986836|AI854628|TM2|Tm3|Tmpa|Tpm-1|alpha-TM
Organism:Mus musculus (Mouse)
Chromosome:9
Genetic Location:9 C|9 40.0 cM
Physical Location:66870399-66897019 on NC_000075.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7168    Symbol (Name): TPM1 (tropomyosin 1 (alpha))
Ortholog Status:The human GeneID 7168 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:1423049 (probe)
Original ID2:Tpm1
Fold Change:1.26
P Value:8.40E-07
Note:Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:5.1
Gene Information
Original ID1:1423721 (probe)
Original ID2:Tpm1
Fold Change:1.16
P Value:1.20E-04
Note:Moderate priority differential expression on 430A array. Direction: B6>D2; Cis LOD:0.8
Dataset Information
Name:15597075
Method:Microarray and QTL
Tissue:Brain
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_024427.4NP_077745.2NC_000075.5 range: 66870399..66897019, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (16765662)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005862muscle thin filament tropomyosinCellular ComponentTAS (8618961)
GO:0030016myofibrilCellular ComponentIDA (9440710|11356630)
GO:0031941filamentous actinCellular ComponentIDA (16765662)
GO:0003779actin bindingMolecular FunctionIEA
GO:0005200structural constituent of cytoskeletonMolecular FunctionTAS (8618961)
GO:0001701in utero embryonic developmentBiological ProcessIMP (9440710)
GO:0009790embryonic developmentBiological ProcessIMP (9400381)
Other Database Cross Links
NCBI Entrez Gene:22003
MGI:
Ensembl:ENSMUSG00000032366
dbSNP:Tpm1
AceView:Tpm1