Gene Information |
Gene ID: | | 17025 |
Symbol: | | Alad |
Full Name: | | aminolevulinate, delta-, dehydratase |
Alias: | | Lv |
Organism: | | Mus musculus (Mouse) |
Chromosome: | | 4 |
Genetic Location: | | 4 B3|4 30.6 cM |
Physical Location: | | 62170203-62181096 on NC_000070.5, complement |
Gene Type: | | protein-coding |
Human Ortholog: | | GeneID: 210 Symbol (Name): ALAD (aminolevulinate, delta-, dehydratase) |
Ortholog Status: | | The human GeneID 210 is also in human dataset(s). |
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Gene in Ethanol Study Datasets |
Gene Information | Original ID1: | | X13752 | Note: | | Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains |
| Dataset Information | Name: | | 15282116 | Method: | | Microarray | Tissue: | | Striata | Phenotype: | | Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration | Publication: | | Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed | Summary: | | Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By. |
| Gene Information | Original ID1: | | 1424877 (probe) | Original ID2: | | Alad | Fold Change: | | 2.1 | P Value: | | 6.60E-10 | Note: | | Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:10.5 |
| Gene Information | Original ID1: | | 101044 (probe) | Original ID2: | | Alad | Fold Change: | | 3.25 | P Value: | | 2.90E-10 | Note: | | Highest priority differential expression on U74Av2 array. Direction: D2>B6; Cis LOD:6.1 |
| Dataset Information | Name: | | 15597075 | Method: | | Microarray and QTL | Tissue: | | Brain | Phenotype: | | Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity | Publication: | | Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed | Summary: | | Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype. |
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Gene Refseq Sequence Annotation |
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Gene Ontology (GO) Annotation |
GO ID | GO Term | Category | Evidence (PubMed) | |
GO:0003824 | catalytic activity | Molecular Function | IEA | |
GO:0042802 | identical protein binding | Molecular Function | IPI (11591653) | |
GO:0016829 | lyase activity | Molecular Function | IEA | |
GO:0008270 | zinc ion binding | Molecular Function | IEA | |
GO:0004655 | porphobilinogen synthase activity | Molecular Function | IEA | |
GO:0046872 | metal ion binding | Molecular Function | IEA | |
GO:0008152 | metabolic process | Biological Process | IEA | |
GO:0006783 | heme biosynthetic process | Biological Process | IEA | |
GO:0006779 | porphyrin biosynthetic process | Biological Process | IEA | |
GO:0033014 | tetrapyrrole biosynthetic process | Biological Process | IEA | |
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Other Database Cross Links |
NCBI Entrez Gene: | | 17025 |
MGI: | |
Ensembl: | | ENSMUSG00000028393 |
dbSNP: | | Alad |
AceView: | | Alad |