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Gene Information
Gene ID:17025
Symbol:Alad
Full Name:aminolevulinate, delta-, dehydratase
Alias:Lv
Organism:Mus musculus (Mouse)
Chromosome:4
Genetic Location:4 B3|4 30.6 cM
Physical Location:62170203-62181096 on NC_000070.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 210    Symbol (Name): ALAD (aminolevulinate, delta-, dehydratase)
Ortholog Status:The human GeneID 210 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X13752
Note:Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains
Dataset Information
Name:15282116
Method:Microarray
Tissue:Striata
Phenotype:Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.
Gene Information
Original ID1:1424877 (probe)
Original ID2:Alad
Fold Change:2.1
P Value:6.60E-10
Note:Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:10.5
Gene Information
Original ID1:101044 (probe)
Original ID2:Alad
Fold Change:3.25
P Value:2.90E-10
Note:Highest priority differential expression on U74Av2 array. Direction: D2>B6; Cis LOD:6.1
Dataset Information
Name:15597075
Method:Microarray and QTL
Tissue:Brain
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008525.3NP_032551.3NC_000070.5 range: 62170203..62181096, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0003824catalytic activityMolecular FunctionIEA
GO:0042802identical protein bindingMolecular FunctionIPI (11591653)
GO:0016829lyase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0004655porphobilinogen synthase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0006783heme biosynthetic processBiological ProcessIEA
GO:0006779porphyrin biosynthetic processBiological ProcessIEA
GO:0033014tetrapyrrole biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:17025
MGI:
Ensembl:ENSMUSG00000028393
dbSNP:Alad
AceView:Alad