ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Alad

Full Name:

aminolevulinate, delta-, dehydratase

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 B3|4 30.6 cM

Physical Location:

62170203-62181096 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 210 Symbol (Name): ALAD (aminolevulinate, delta-, dehydratase)

Ortholog Status:

The human GeneID 210 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X13752
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Information

Original ID1:		1424877 (probe)
Original ID2:		Alad
Fold Change:		2.1
P Value:		6.60E-10
Note:		Highest priority differential expression on 430A array. Direction: D2>B6; Cis LOD:10.5

Gene Information

Original ID1:		101044 (probe)
Original ID2:		Alad
Fold Change:		3.25
P Value:		2.90E-10
Note:		Highest priority differential expression on U74Av2 array. Direction: D2>B6; Cis LOD:6.1

Dataset Information

Name:		15597075
Method:		Microarray and QTL
Tissue:		Brain
Phenotype:		Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:		Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:		Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008525.3	NP_032551.3	NC_000070.5 range: 62170203..62181096, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (11591653)
GO:0016829	lyase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004655	porphobilinogen synthase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006783	heme biosynthetic process	Biological Process	IEA
GO:0006779	porphyrin biosynthetic process	Biological Process	IEA
GO:0033014	tetrapyrrole biosynthetic process	Biological Process	IEA